N-[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-4-[3-[[[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]carbamoyl]propylsulfanyl]butanehydrazide

Modify Date: 2026-07-17 12:40:11

N-[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-4-[3-[[[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]carbamoyl]propylsulfanyl]butanehydrazide structure	Common Name	N-[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-4-[3-[[[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]carbamoyl]propylsulfanyl]butanehydrazide
	CAS Number	6325-13-9	Molecular Weight	442.53
	Density	1.351g/cm3	Boiling Point	621.9ºC at 760 mmHg
	Molecular Formula	C₂₂H₂₆N₄O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	329.9ºC

Use of N-[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-4-[3-[[[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]carbamoyl]propylsulfanyl]butanehydrazide

Nrf2-IN-3 (Compound R16) is a Nrf2 inhibitor. Nrf2-IN-3 binds KEAP1 mutants (G333C mKEAP1) and repairs the disrupted KEAP1/NRF2 interactions. Nrf2-IN-3 sensitizes KEAP1-mutated cancer cells to Cisplatin (HY-17394) and Gefitinib (HY-50895) by repairing the mKEAP1/NRF2 complex[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Nrf2-IN-3 (Compound R16) is a Nrf2 inhibitor. Nrf2-IN-3 binds KEAP1 mutants (G333C mKEAP1) and repairs the disrupted KEAP1/NRF2 interactions. Nrf2-IN-3 sensitizes KEAP1-mutated cancer cells to Cisplatin (HY-17394) and Gefitinib (HY-50895) by repairing the mKEAP1/NRF2 complex[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> NF-κB >> Keap1-Nrf2
References	[1]. Aboulkassim T, et al. A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants. Cell Rep. 2023 Sep 12;42(9):113104.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.351g/cm3
Boiling Point	621.9ºC at 760 mmHg
Molecular Formula	C₂₂H₂₆N₄O₄S
Molecular Weight	442.53
Flash Point	329.9ºC
Exact Mass	442.16700
PSA	148.68000
LogP	3.77360
Index of Refraction	1.681
InChIKey	MWGPMYRFUXZJAS-UHFFFAOYSA-N
SMILES	O=C(CCCSCCCC(=O)NN=Cc1ccccc1O)NN=Cc1ccccc1O

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

4,4'-Sulfandiyl-di-buttersaeure-bis-salicylidenhydrazid

4,4'-sulfanediyl-di-butyric acid bis-salicylidenehydrazide

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the uses of N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide?

A: Main uses of N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide: Nrf2-IN-3 (Compound R16) is a Nrf2 inhibitor. Nrf2-IN-3 binds KEAP1 mutants (G333C mKEAP1) and repairs the disrupted KEAP1/NRF2 interactions. Nrf2-IN-3 sensitizes KEAP1-mutated cancer cells to Cisplatin (HY-17394) and Gefitinib (HY-50895) by repairing the mKEAP1/NRF2 complex[1].

Q: What is the molecular weight of N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide?

A: Molecular weight of N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide is 442.53.

Q: What is the English name of N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide?

A: The English name of N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide is N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide.

Q: What is the SMILES notation of N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide?

A: SMILES notation of N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide is O=C(CCCSCCCC(=O)NN=Cc1ccccc1O)NN=Cc1ccccc1O.

Q: What is the boiling point of N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide?

A: Boiling point of N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide is 621.9ºC at 760 mmHg.

Q: What is the Chinese name of 6325-13-9?

A: Chinese name of 6325-13-9 is 6325-13-9.

Q: What is the InChIKey of N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide?

A: InChIKey of N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide is MWGPMYRFUXZJAS-UHFFFAOYSA-N.

Q: What English synonyms does N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide have?

A: English synonyms of N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide: 4,4'-Sulfandiyl-di-buttersaeure-bis-salicylidenhydrazid, 4,4'-sulfanediyl-di-butyric acid bis-salicylidenehydrazide.

Q: What is the CAS number of N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide?

A: CAS number of N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide is 6325-13-9.

Q: What is the polar surface area (PSA) of N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide?

A: Polar surface area (PSA) of N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-4-[4-oxo-4-[2-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]hydrazinyl]butyl]sulfanylbutanehydrazide is 148.68000.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Dayang Chem (Hangzhou) Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

N-[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-4-[3-[[[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]carbamoyl]propylsulfanyl]butanehydrazide

Use of N-[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-4-[3-[[[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]carbamoyl]propylsulfanyl]butanehydrazide

Names

Biological Activity

Chemical & Physical Properties

Synonyms

| FAQ

factory

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.