AH-7614
Modify Date: 2026-07-10 18:26:37
AH-7614 structure
|
Common Name | AH-7614 | ||
|---|---|---|---|---|
| CAS Number | 6326-06-3 | Molecular Weight | 351.41900 | |
| Density | 1.37g/cm3 | Boiling Point | 505.9ºC at 760mmHg | |
| Molecular Formula | C20H17NO3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 259.8ºC | |
Use of AH-7614AH-7614 is a potent and selective FFA4 antagonist, with pIC50s of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. AH-7614 has selectivity for FFA4 over FFA1 (pIC50<4.6). AH-7614 is also a negative allosteric modulator (NAM) of FFA4. AH-7614 is able to block effects of both the polyunsaturated ω-6 fatty acid linoleic acid and the synthetic FFA4 agonist[1][2]. |
| Name | N-Xanthen-9-yl-toluol-4-sulfonamid |
|---|---|
| Synonym | More Synonyms |
| Description | AH-7614 is a potent and selective FFA4 antagonist, with pIC50s of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. AH-7614 has selectivity for FFA4 over FFA1 (pIC50<4.6). AH-7614 is also a negative allosteric modulator (NAM) of FFA4. AH-7614 is able to block effects of both the polyunsaturated ω-6 fatty acid linoleic acid and the synthetic FFA4 agonist[1][2]. |
|---|---|
| Related Catalog | |
| Target |
pIC50: 7.1 (human FFA4)[1] |
| In Vitro | AH-7614 (compound 39) (0.063-1 μM) blocks intracellular Ca2+ response induced by both linoleic acid and FFAR4 agonist in FFA4 expressing U2OS cells[1]. AH-7614 (100 μM) abolishes the enhancement in glucose-stimulated insulin secretion by GSK137647A in NCI-H716 cells[1]. AH-7614 (0.001-10 μM; 15 min) blocks TUG-891-mediated internalization of FFA4 from the cell surface (pIC50=7.70)[2]. AH-7614 (10 μM; 30 min) blocks agonist-induced elevation of intracellular inositol monophosphates and phosphorylation of FFA4[2]. |
| In Vivo | AH7614 (50 μg; intratumoral injection once every 4 d for 20 d) reduces the tumor growth in mice[3]. AH7614 (50 μg; intratumoral injection one day prior to epirubicin injection) enhances cancer cell sensitivity to the chemotherapy and inhibit tumor progression by blocking GPR120 signaling in combination with Epirubicin[3]. |
| References |
| Density | 1.37g/cm3 |
|---|---|
| Boiling Point | 505.9ºC at 760mmHg |
| Molecular Formula | C20H17NO3S |
| Molecular Weight | 351.41900 |
| Flash Point | 259.8ºC |
| Exact Mass | 351.09300 |
| PSA | 63.78000 |
| LogP | 5.64030 |
| Index of Refraction | 1.685 |
| InChIKey | OZCQEUZTOAAWDK-UHFFFAOYSA-N |
| SMILES | Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1 |
| HS Code | 2935009090 |
|---|
![[N-(p-Toluenesulfonyl)imino]phenyliodinane structure](https://image.chemsrc.com/caspic/449/55962-05-5.png)
| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
|
Name: Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium m...
Source: ChEMBL
Target: Free fatty acid receptor 4
External Id: CHEMBL3364891
|
|
Name: Thermal Shift Assay. Domain: start/stop: M1-L298
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL5062802
|
|
Name: A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS979
|
|
Name: Thermal Shift Assay. Domain: start/stop: M1-S360
Source: ChEMBL
Target: Mitogen-activated protein kinase 1
External Id: CHEMBL5066877
|
|
Name: Thermal Shift Assay. Domain: start/stop: M1-L298
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL5063161
|
|
Name: Thermal Shift Assay. Domain: start/stop: M26-R383
Source: ChEMBL
Target: Glycogen synthase kinase-3 beta
External Id: CHEMBL5065589
|
|
Name: Thermal Shift Assay. Domain: start/stop: S229-K512
Source: ChEMBL
Target: Tyrosine-protein kinase ABL1
External Id: CHEMBL5060015
|
|
Name: GPCR beta-arrestin recruitment assay with target: FPR2 Assay Type: PRESTO-Tango Conce...
Source: ChEMBL
Target: N-formyl peptide receptor 2
External Id: CHEMBL5209826
|
|
Name: GPCR beta-arrestin recruitment assay with target: GLP1R Assay Type: PRESTO-Tango Conc...
Source: ChEMBL
Target: Glucagon-like peptide 1 receptor
External Id: CHEMBL5209829
|
|
Name: GPCR beta-arrestin recruitment assay with target: FFAR4 Assay Type: PRESTO-Tango Conc...
Source: ChEMBL
Target: Free fatty acid receptor 4
External Id: CHEMBL5209823
|
Total 61, Current Page 1 of 7
1
2
3
4
5
| 4-methyl-N-9H-xanthen-9-yl-Benzamide |
| N-xanthen-9-yl-p-toluamide |
| N-xanthen-9-yl-toluene-4-sulfonamide |
| N-xanthyl-p-toluenesulfonamide |