4-Chloro-3-nitroaniline

Modify Date: 2024-01-06 15:07:32

4-Chloro-3-nitroaniline structure	Common Name	4-Chloro-3-nitroaniline
	CAS Number	635-22-3	Molecular Weight	172.56900
	Density	1.494 g/cm3	Boiling Point	344.5ºC at 760 mmHg
	Molecular Formula	C₆H₅ClN₂O₂	Melting Point	99-101 °C(lit.)
	MSDS	Chinese USA	Flash Point	162.2ºC
	Symbol	GHS06, GHS08, GHS09	Signal Word	Danger

Name	4-Chloro-3-nitroaniline
Synonym	More Synonyms

Density	1.494 g/cm3
Boiling Point	344.5ºC at 760 mmHg
Melting Point	99-101 °C(lit.)
Molecular Formula	C₆H₅ClN₂O₂
Molecular Weight	172.56900
Flash Point	162.2ºC
Exact Mass	172.00400
PSA	71.84000
LogP	2.93480
Index of Refraction	1.646

4-Chloro-3-nitroaniline MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BX1750000

CHEMICAL NAME :: Aniline, 4-chloro-3-nitro-

CAS REGISTRY NUMBER :: 635-22-3

BEILSTEIN REFERENCE NO. :: 1309394

LAST UPDATED :: 199710

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C6-H5-Cl-N2-O2

MOLECULAR WEIGHT :: 172.58

WISWESSER LINE NOTATION :: ZR DG CNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0882-0452

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0882-0452 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0882-0452

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0882-0452

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0882-0452

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0882-0452

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0882-0452

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5850 mg/kg/90D-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Blood - other hemolysis with or without anemia Related to Chronic Data - changes in testicular weight

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,551,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9772 mg/kg/14D-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in erythrocyte (RBC) count Related to Chronic Data - changes in testicular weight

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0882-0452 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5850 mg/kg

SEX/DURATION :: male 90 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,551,1986 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993

Symbol	GHS06, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H300-H310-H330-H373-H411
Precautionary Statements	P260-P264-P273-P280-P284-P302 + P350
Hazard Codes	T+:Verytoxic;N:Dangerous for the environment;
Risk Phrases	R26/27/28;R33;R51/53
Safety Phrases	S28-S36/37-S45-S61-S28A
RIDADR	UN 2237 6.1/PG 3
WGK Germany	3
RTECS	BX1750000
Packaging Group	III
Hazard Class	6.1
HS Code	29214210

Precursor 10
CAS#:97-00-7 2,4-Dinitrochlo... CAS#:106-47-8 4-Chloroaniline CAS#:99-09-2 3-Nitroaniline CAS#:112160-74-4 acetic acid-(2,...
CAS#:7664-93-9 Sulfuric acid CAS#:7697-37-2 nitric acid CAS#:7647-01-0 Hydrochloric acid CAS#:67-66-3 Chloroform
CAS#:67-56-1 Methanol CAS#:7782-50-5 Chlorine
DownStream 10
CAS#:60811-17-8 ZR BG EE CAS#:341010-40-0 5-Amino-6-chlor... CAS#:939-80-0 4-Chloro-3-nitr... CAS#:51461-11-1 N-(3-Amino-4-ch...
CAS#:913836-26-7 4-Chloro-3-Nitr... CAS#:226073-82-1 6-Chloro-7-nitr... CAS#:86984-32-9 6-Chloro-5-nitr... CAS#:96-99-1 4-Chloro-3-nitr...
CAS#:89-61-2 1,4-Dichloro-2-... CAS#:63134-29-2 N-(4-CHLORO-3-N...

HS Code	2921420090
Summary	HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Influence of strain and sex on the metabolic profile of rats in repeated dose toxicological studies.

Toxicol. Lett. 191(1) , 88-95, (2009)

The impact of the strain on the metabolite profile of plasma samples in rats dosed with 2500 ppm 2-methyl-4-chlorophenoxyacetic acid (MCPA acid) or 45 mg/kg bw/day 4-chloro-3-nitroaniline (4C3N) for 4...

Subchronic oral toxicology of 4-chloro-3-nitroaniline in the rat.

Fundam. Appl. Toxicol. 6(3) , 551-8, (1986)

4-Chloro-3-nitroaniline was given to groups of 20 male and 20 female rats by gavage at doses of 3.6, 18, or 90 mg/kg in a 10% corn oil suspension. Doses were administered 5 days per week for 90 days. ...

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-Chloro-3-nitroaniline
Price: Click To Check
Purity: 99.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4-Chloro-3-nitroaniline
Price: ￥118.0/25g ￥348.0/100g
Purity: 99.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Chloro-3-nitroaniline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4-Chloro-3-nitroaniline
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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