AEG 3482
Modify Date: 2026-07-01 20:29:51
AEG 3482 structure
|
Common Name | AEG 3482 | ||
|---|---|---|---|---|
| CAS Number | 63735-71-7 | Molecular Weight | 280.326 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C10H8N4O2S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of AEG 3482AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25[1]. |
| Name | 6-phenylimidazo[2,1-b][1,3,4]thiadiazole-2-sulfonamide |
|---|---|
| Synonym | More Synonyms |
| Description | AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25[1]. |
|---|---|
| Related Catalog | |
| Target |
JNK[1] |
| In Vitro | AEG3482 (0.3-30 μM; 2 d) inhibits nerve growth factor (NGF) withdrawal-induced death in SCG neurons, with an EC50 of ∼20 μM[1]. AEG3482 (1-80 μM; 40 h) inhibits p75NTR- and NRAGE- mediated apoptosis of PC12 cells in a dose-dependent manner[1]. AEG3482 (10-40 μM; 30 h) inhibits p75NTR- and NRAGE-mediated JNK activation in PC12 cells[1]. Apoptosis Analysis[1] Cell Line: PC12 cells Concentration: 1, 2.5, 5, 10, 20, 40, 80 μM Incubation Time: 40 hours Result: Reduced p75NTR- or NRAGE-induced cell death by greater than 90% at the concentration of 40 μM. Exerted a slight toxic effect in cells infected with the LacZ control at the concentration of 80 μM. Western Blot Analysis[1] Cell Line: PC12 cells Concentration: 10, 20, 40 μM Incubation Time: 30 hours Result: Attenuated p75NTR- and NRAGE-induced c-Jun phosphorylation and caspase-3 cleavage, and the levels of c-Jun protein. |
| References |
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Molecular Formula | C10H8N4O2S2 |
| Molecular Weight | 280.326 |
| Exact Mass | 280.008881 |
| PSA | 126.97000 |
| LogP | 1.32 |
| Index of Refraction | 1.835 |
| InChIKey | MQUYTXDAVCOCMX-UHFFFAOYSA-N |
| SMILES | NS(=O)(=O)c1nn2cc(-c3ccccc3)nc2s1 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
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Name: Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
Source: NCGC
Target: N/A
External Id: SERCaMPGLuc-p1-antagonist
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Name: In vitro inhibition of carbonic anhydrase was determined using enzyme prepared from m...
Source: ChEMBL
Target: N/A
External Id: CHEMBL662692
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Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315
|
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Name: Hit confirmation of the active molecules of the enzymatic assay of human HDAC6 with c...
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808151
|
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Name: A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS979
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Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582
|
|
Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library
|
|
Name: Enzymatic assay of human HDAC6 with commercial peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808149
|
|
Name: 7124-02: inhibition of TNFa signaling in B cell lineage, counterscreen
Source: Broad Institute
Target: N/A
External Id: 7124-02_CD40 Signaling Pathway_CD40 TNFa Counterscreen
|
|
Name: Enzymatic assay of human HDAC6 with custom peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808150
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| hms1538b12 |
| 6-Phenylimidazo[2,1-b][1,3,4]thiadiazole-2-sulfonamide |
| unii-7ezf1a283n |