Ethyl 2-Chloroacetoacetate

Modify Date: 2026-06-30 20:49:19

Ethyl 2-Chloroacetoacetate structure	Common Name	Ethyl 2-Chloroacetoacetate
	CAS Number	638-07-3	Molecular Weight	164.587
	Density	1.2±0.1 g/cm3	Boiling Point	235.5±0.0 °C at 760 mmHg
	Molecular Formula	C₆H₉ClO₃	Melting Point	-8 °C
	MSDS	Chinese USA	Flash Point	96.7±0.0 °C
	Symbol	GHS05, GHS06	Signal Word	Danger

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	Ethyl 4-chloroacetoacetate
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.2±0.1 g/cm3
Boiling Point	235.5±0.0 °C at 760 mmHg
Melting Point	-8 °C
Molecular Formula	C₆H₉ClO₃
Molecular Weight	164.587
Flash Point	96.7±0.0 °C
Exact Mass	164.024017
PSA	43.37000
LogP	1.54
Vapour Pressure	0.1±0.4 mmHg at 25°C
Index of Refraction	1.436
InChIKey	OHLRLMWUFVDREV-UHFFFAOYSA-N
SMILES	CCOC(=O)CC(=O)CCl
Storage condition	2-8°C
Water Solubility	47.5 g/L (20 ºC)

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Ethyl 2-Chloroacetoacetate MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AK5110000

CHEMICAL NAME :: Acetoacetic acid, 4-chloro-, ethyl ester

CAS REGISTRY NUMBER :: 638-07-3

BEILSTEIN REFERENCE NO. :: 1761275

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C6-H9-Cl-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Skin and Appendages - hair

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555360

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 108 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,695,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Skin and Appendages - hair

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555360

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 88 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,695,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg/15D-I

TOXIC EFFECTS :: Gastrointestinal - gastritis Gastrointestinal - ulceration or bleeding from stomach Liver - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555360

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS05, GHS06
Signal Word	Danger
Hazard Statements	H301-H314
Precautionary Statements	P280-P301 + P310-P305 + P351 + P338-P310
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	T:Toxic;N:Dangerousfortheenvironment;
Risk Phrases	R24/25;R34;R51/53
Safety Phrases	S26-S36-S45-S61-S36/37/39
RIDADR	UN 2922 8/PG 2
WGK Germany	3
RTECS	AK5110000
Packaging Group	II
Hazard Class	8
HS Code	2918990090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

ETHYL 4,4-DICHL...

CAS#:6082-74-2

~66%

Ethyl 2-Chloroa...

CAS#:638-07-3

Learn More

Literature: Terent'ev; Vasil'eva; Mysova; Chakhovskaya Russian Journal of Organic Chemistry, 2004 , vol. 40, # 7 p. 924 - 927

4-chloro-3-oxob...

CAS#:41295-64-1

Ethanol

CAS#:64-17-5

Ethyl 2-Chloroa...

CAS#:638-07-3

Learn More

Literature: EP2518043 A1, ; Page/Page column 10; 11 ;

2-Hexanone

CAS#:591-78-6

ETHYL 4,4-DICHL...

CAS#:6082-74-2

~40%

Ethyl 2-Chloroa...

CAS#:638-07-3

Ethyl acetoacetate

CAS#:141-97-9

Learn More

Literature: Russian Journal of Organic Chemistry, , vol. 40, # 7 p. 924 - 927

ETHYL 4,4-DICHL...

CAS#:6082-74-2

Benzaldehyde

CAS#:100-52-7

~71%

Ethyl 2-Chloroa...

CAS#:638-07-3

ethyl 3-oxo-5-p...

CAS#:1503-99-7

Learn More

Literature: Terent'ev; Vasil'eva; Mysova; Chakhovskaya Russian Journal of Organic Chemistry, 2004 , vol. 40, # 7 p. 924 - 927

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 5
CAS#:6082-74-2 ETHYL 4,4-DICHL... CAS#:41295-64-1 4-chloro-3-oxob... CAS#:64-17-5 Ethanol CAS#:591-78-6 2-Hexanone
CAS#:100-52-7 Benzaldehyde
DownStream 9
CAS#:106302-03-8 (3-ETHOXYCARBON... CAS#:105435-14-1 diethyl 2-(chlo... CAS#:34265-58-2 ETHYL 2-HYDROXY... CAS#:40207-03-2 Hydrazinecarbot...
CAS#:787-07-5 Diethyl succino... CAS#:38220-75-6 ETHANONE, 1-(5-... CAS#:41051-21-2 octyl 4-chloro-... CAS#:59128-02-8 Ethyl (6-chloro...
CAS#:43071-52-9 2-acetyl-7-meth...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2918300090
Summary	2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Construction of a two-strain system for asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to (S)-4-chloro-3-hydroxybutanoate ethyl ester.

Appl. Microbiol. Biotechnol. 70(1) , 40-6, (2006)

Escherichia coli M15 (pQE30-car0210) was constructed to express carbonyl reductase (CAR) by cloning the car gene from Candida magnoliae and inserting it into pQE30. By cultivating E. coli M15 (pQE30-c...

Purification and characterization of an alpha-haloketone-resistant formate dehydrogenase from Thiobacillus sp. strain KNK65MA, and cloning of the gene.

Biosci. Biotechnol. Biochem. 67(10) , 2145-53, (2003)

Thiobacillus sp. strain KNK65MA, which produced an NAD-dependent formate dehydrogenase (FDH) highly resistant to alpha-haloketones, was newly isolated, i.e., the enzyme showed no loss of activity afte...

A novel carbonyl reductase from Pichia stipitis for the production of ethyl (S)-4-chloro-3-hydroxybutanoate.

Biotechnol. Lett. 31(4) , 537-42, (2009)

An NADPH-dependent carbonyl reductase (PsCR) gene from Pichia stipitis was cloned. It contains an open reading frame of 849 bp encoding 283 amino acids whose sequence had less than 60% identity to kno...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: qHTS assay to identify small molecule antagonists of the peroxisome proliferator-acti...
Source: 824
Target: N/A
External Id: PPARGV841

Name: qHTS assay to identify small molecule agonists of the TGF-beta/Smad signaling pathway...
Source: 824
Target: N/A
External Id: TGF788

Name: qHTS assay to identify small molecule antagonists of the TGF-beta/Smad signaling path...
Source: 824
Target: N/A
External Id: TGF602

Name: qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell fr...
Source: 824
Target: N/A
External Id: SPEC167MG

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: qHTS assay to identify small molecule agonists of the peroxisome proliferator-activat...
Source: 824
Target: N/A
External Id: PPARDV813

Name: qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cell free...
Source: 824
Target: N/A
External Id: SPEC167MR

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells
Source: 824
Target: N/A
External Id: SPEC167CG

Total 186, Current Page 1 of 19

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

4-chloro ethyl acetoacetate

Ethyl4-chloroacetoacetate

Ethyl (chloroacetyl)acetate

Butanoic acid, 4-chloro-3-oxo-, ethyl ester

Butanoic acid, 4-chloro-3-oxo-ethylester

Ethyl g-chloroacetoacetate

Ethyl-4-chloracetoacetat

Ethyl 4-chloroacetoa

Ethyl 4-chloro-3-oxobutyrate

4-Chloro-acetoacetic

ethyl 2-chloro-acetoacetate

Ethyl 4-chloro-3-oxobutanoate

MFCD00000939

Ethyl-4chloroacetaacetate

Ethyl 2-Chloroacetoacetate

Ethyl α-chloroacetoacetate

2-Chloroacetoacetic acid ethyl ester

Ethyl 4-chloroacetoacetate

EINECS 211-317-0

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the melting point of Ethyl 4-chloroacetoacetate?

A: Melting point of Ethyl 4-chloroacetoacetate is -8 °C.

Q: What is the LogP of Ethyl 4-chloroacetoacetate?

A: LogP of Ethyl 4-chloroacetoacetate is 1.54.

Q: What is the polar surface area (PSA) of Ethyl 4-chloroacetoacetate?

A: Polar surface area (PSA) of Ethyl 4-chloroacetoacetate is 43.37000.

Q: What is the safety information for Ethyl 4-chloroacetoacetate?

A: Safety information for Ethyl 4-chloroacetoacetate: S26-S36-S45-S61-S36/37/39.

Q: What is the English name of Ethyl 4-chloroacetoacetate?

A: The English name of Ethyl 4-chloroacetoacetate is Ethyl 4-chloroacetoacetate.

Q: How is the water solubility of Ethyl 4-chloroacetoacetate?

A: Water solubility of Ethyl 4-chloroacetoacetate: 47.5 g/L (20 ºC).

Q: What are the storage conditions for Ethyl 4-chloroacetoacetate?

A: Storage conditions for Ethyl 4-chloroacetoacetate: 2-8°C.

Q: What are the downstream products of Ethyl 4-chloroacetoacetate?

A: Related downstream products(CAS) of Ethyl 4-chloroacetoacetate: 106302-03-8;105435-14-1;34265-58-2;40207-03-2;787-07-5;38220-75-6;41051-21-2;59128-02-8;43071-52-9.

Q: What is the molecular formula of Ethyl 4-chloroacetoacetate?

A: Molecular formula of Ethyl 4-chloroacetoacetate is C6H9ClO3.

Q: What is the boiling point of Ethyl 4-chloroacetoacetate?

A: Boiling point of Ethyl 4-chloroacetoacetate is 235.5±0.0 °C at 760 mmHg.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Ethyl 2-Chloroacetoacetate
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ethyl 4-chloroacetoacetate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Ethyl 4-Chloroacetoacetate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: Ethyl 2-Chloroacetoacetate
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

Get all suppliers and price by the below link:

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Ethyl 2-Chloroacetoacetate price

Ethyl 2-Chloroacetoacetate

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.