Tetracycline hydrochloride

Modify Date: 2026-06-30 17:19:27

Tetracycline hydrochloride structure	Common Name	Tetracycline hydrochloride
	CAS Number	64-75-5	Molecular Weight	480.896
	Density	N/A	Boiling Point	799.4ºC at 760 mmHg
	Molecular Formula	C₂₂H₂₅ClN₂O₈	Melting Point	220-223 °C(lit.)
	MSDS	Chinese USA	Flash Point	437.3ºC
	Symbol	GHS07	Signal Word	Warning

Use of Tetracycline hydrochloride

Tetracycline hydrochloride is a broad-spectrum antibiotic used to treat a wide range of infections.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	Tetracycline hydrochloride
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Tetracycline hydrochloride is a broad-spectrum antibiotic used to treat a wide range of infections.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
In Vitro	Tetracyclines are broad-spectrum agents, exhibiting activity against a wide range of gram-positive and gram-negative bacteria, atypical organisms such as chlamydiae, mycoplasmas, and rickettsiae, and protozoan parasites. Tetracyclines inhibit bacterial protein synthesis by preventing the association of aminoacyl-tRNA with the bacterial ribosome. Tetracyclines traverse the outer membrane of gram-negative enteric bacteria through the OmpF and OmpC porin channels, as positively charged cation (probably magnesium)-tetracycline coordination complexes [1].
In Vivo	The tetracyclines have applications for the treatment of infections in poultry, cattle, sheep, and swine. In some cases, e.g., for therapeutic treatment of large numbers of poultry reared on commercial farms, the antibiotics are added directly to feed or water or can be administered in aerosols. Tetracyclines could be used as growth promotion or growth enhancement. Tetracyclines are used in aquaculture to control infections in salmon, catfish, and lobsters[2].
References	[1]. Chopra I, et al.Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology ofbacterial resistance.Microbiol Mol Biol Rev. 2001 Jun;65(2):232-60

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Boiling Point	799.4ºC at 760 mmHg
Melting Point	220-223 °C(lit.)
Molecular Formula	C₂₂H₂₅ClN₂O₈
Molecular Weight	480.896
Flash Point	437.3ºC
Exact Mass	480.129944
PSA	181.62000
LogP	1.28790
Vapour Pressure	5.82E-27mmHg at 25°C
Index of Refraction	-253 ° (C=0.5, 0.1mol/L HCl)
InChIKey	YCIHPQHVWDULOY-FMZCEJRJSA-N
SMILES	CN(C)C1C(=O)C(C(N)=O)=C(O)C2(O)C(=O)C3=C(O)c4c(O)cccc4C(C)(O)C3CC12.Cl
Water Solubility	50 g/L

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Tetracycline hydrochloride MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QI9100000

CHEMICAL NAME :: 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6, 10,12,12a- pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride

CAS REGISTRY NUMBER :: 64-75-5

LAST UPDATED :: 199707

DATA ITEMS CITED :: 44

MOLECULAR FORMULA :: C22-H24-N2-O8.Cl-H

MOLECULAR WEIGHT :: 480.94

WISWESSER LINE NOTATION :: L E6 C666 BV FV CU GUTTT&J DQ EQ GVZ HQ IN1&1 MQ M1 RQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 200 mg/kg/7D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Taste) - change in function

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6443 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 318 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 128 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2759 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 368 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 157 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 105 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 210 mg/kg/7D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1287 mg/kg/30D-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg/20D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - other changes Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 14 gm/kg

SEX/DURATION :: male 3 day(s) pre-mating female 3 day(s) pre-mating - 22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6 gm/kg

SEX/DURATION :: female 9-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 425 mg/kg

SEX/DURATION :: female 14-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 240 mg/kg

SEX/DURATION :: female 16-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 240 mg/kg

SEX/DURATION :: female 10-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 450 mg/kg

SEX/DURATION :: female 7-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 765 mg/kg

SEX/DURATION :: female 7-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intrauterine

DOSE :: 100 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 900 mg/kg

SEX/DURATION :: female 8-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 600 mg/kg

SEX/DURATION :: female 8-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 150 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 2250 mg/kg

SEX/DURATION :: female 10-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 750 mg/kg

SEX/DURATION :: female 1-6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 2250 mg/kg

SEX/DURATION :: female 10-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 9 gm/kg

SEX/DURATION :: female 8-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 3 mg/L

REFERENCE :: SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20 Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949- Volume(issue)/page/year: 74,1385,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83550 No. of Facilities: 474 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 1795 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83550 No. of Facilities: 680 (estimated) No. of Industries: 4 No. of Occupations: 15 No. of Employees: 22901 (estimated) No. of Female Employees: 17276 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	QI9100000
HS Code	29413000

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

Tetracycline

CAS#:60-54-8

Tetracycline hy...

CAS#:64-75-5

Learn More

Literature: WO2005/112945 A2, ; Page/Page column 106-107 ;

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 1
CAS#:60-54-8 Tetracycline
DownStream 1
CAS#:60-54-8 Tetracycline

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	29413000

This table lists relevant public references with title, journal and publication metadata for this compound.

Selective growth-inhibitory effect of 8-hydroxyquinoline towards Clostridium difficile and Bifidobacterium longum subsp. longum in co-culture analysed by flow cytometry.

J. Med. Microbiol. 63(Pt 12) , 1663-9, (2014)

The major risk factor for Clostridium difficile infection (CDI) is the use of antibiotics owing to the disruption of the equilibrium of the host gut microbiota. To preserve the beneficial resident pro...

Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing.

Bioorg. Med. Chem. Lett. 22 , 1709-11, (2012)

Over-expressions of miRNAs are being increasingly linked with many diseases including different types of cancer. In this study, the role of some known small molecular therapeutics has been investigate...

Development of a Method for the Analysis of Multiclass Antibiotic Residues in Milk Using QuEChERS and Liquid Chromatography-Tandem Mass Spectrometry.

Foodborne Pathog. Dis. 12 , 693-703, (2015)

A precise and simplified method of sample preparation for the simultaneous quantification of the antibiotics β-lactam, macrolide, tetracycline, sulfonamide, and quinolone in bovine milk was developed....

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Antimicrobial activity against Bifidobacterium thermophilum ATCC 25866
Source: ChEMBL
Target: Bifidobacterium thermophilum
External Id: CHEMBL910836

Name: Antimicrobial activity against Bifidobacterium breve R0070
Source: ChEMBL
Target: Bifidobacterium breve
External Id: CHEMBL910837

Name: Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium animalis ATCC ...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL910838

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Antimicrobial activity against 60 min 1 M HCl-stressed Bifidobacterium bifidum R0071 ...
Source: ChEMBL
Target: Bifidobacterium bifidum
External Id: CHEMBL910839

Name: Antimicrobial activity against Bifidobacterium longum ATCC 15708
Source: ChEMBL
Target: Bifidobacterium longum
External Id: CHEMBL910832

Name: Antimicrobial activity against Bifidobacterium longum R0175
Source: ChEMBL
Target: Bifidobacterium longum
External Id: CHEMBL910833

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Antimicrobial activity against Bifidobacterium longum P/N 601377
Source: ChEMBL
Target: Bifidobacterium longum
External Id: CHEMBL910834

Name: Antimicrobial activity against Bifidobacterium pseudolongum ATCC 25562
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL910835

Total 366, Current Page 1 of 37

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

achromycin hydrochloride

paltet

u-5965

EINECS 200-593-8

alatet

partrex

Tetracycline (hydrochloride)

tetracycline HCl

teline

MFCD00078142

sumycin

tet-cy

quatrex

qidtet

unicin

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the downstream products of Tetracycline hydrochloride?

A: Related downstream products(CAS) of Tetracycline hydrochloride: 60-54-8.

Q: What English synonyms does Tetracycline hydrochloride have?

A: English synonyms of Tetracycline hydrochloride: achromycin hydrochloride, paltet, u-5965, EINECS 200-593-8, alatet, partrex, Tetracycline (hydrochloride), tetracycline HCl, teline, MFCD00078142, sumycin, tet-cy, quatrex, qidtet, unicin.

Q: What is the InChIKey of Tetracycline hydrochloride?

A: InChIKey of Tetracycline hydrochloride is YCIHPQHVWDULOY-FMZCEJRJSA-N.

Q: What is the safety information for Tetracycline hydrochloride?

A: Safety information for Tetracycline hydrochloride: S26-S36.

Q: What is the English name of Tetracycline hydrochloride?

A: The English name of Tetracycline hydrochloride is Tetracycline hydrochloride.

Q: What is the CAS number of Tetracycline hydrochloride?

A: CAS number of Tetracycline hydrochloride is 64-75-5.

Q: How is the water solubility of Tetracycline hydrochloride?

A: Water solubility of Tetracycline hydrochloride: 50 g/L.

Q: What are the uses of Tetracycline hydrochloride?

A: Main uses of Tetracycline hydrochloride: Tetracycline hydrochloride is a broad-spectrum antibiotic used to treat a wide range of infections.

Q: What is the LogP of Tetracycline hydrochloride?

A: LogP of Tetracycline hydrochloride is 1.28790.

Q: What is the boiling point of Tetracycline hydrochloride?

A: Boiling point of Tetracycline hydrochloride is 799.4ºC at 760 mmHg.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Tetracycline hydrochloride
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Tetracycline hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Tetracycline HCl
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Get all suppliers and price by the below link:

Tetracycline hydrochloride suppliers

Price: ￥39/10g

Reference only. check more Tetracycline hydrochloride price

Tetracycline hydrochloride

Use of Tetracycline hydrochloride

Names