Paroxetine maleate

Modify Date: 2024-01-13 14:55:16

Paroxetine maleate Structure
Paroxetine maleate structure
Common Name Paroxetine maleate
CAS Number 64006-44-6 Molecular Weight 445.44
Density 1.213 g/cm3 Boiling Point 451.7ºC at 760 mmHg
Molecular Formula C23H24FNO7 Melting Point 136-138ºC
MSDS Chinese USA Flash Point 227ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of Paroxetine maleate


Paroxetine maleate is a potent and selective inhibitor of SSRI. Paroxetine maleate is used in generalized anxiety disorder, post traumatic stress disorder, premenstrual dysphoric disorder and chronic headache research[1].

 Names

Name paroxetine maleate
Synonym More Synonyms

 Paroxetine maleate Biological Activity

Description Paroxetine maleate is a potent and selective inhibitor of SSRI. Paroxetine maleate is used in generalized anxiety disorder, post traumatic stress disorder, premenstrual dysphoric disorder and chronic headache research[1].
Related Catalog
References

[1]. Bourin M, et al. Paroxetine: a review. CNS Drug Rev. 2001 Spring;7(1):25-47.  

 Chemical & Physical Properties

Density 1.213 g/cm3
Boiling Point 451.7ºC at 760 mmHg
Melting Point 136-138ºC
Molecular Formula C23H24FNO7
Molecular Weight 445.44
Flash Point 227ºC
Exact Mass 445.15400
PSA 114.32000
LogP 3.36710
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM4569300
CHEMICAL NAME :
Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl )-, trans-(-)-, (Z)-2- butenedioate
CAS REGISTRY NUMBER :
64006-44-6
LAST UPDATED :
199707
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C19-H20-F-N-O3.xC4-H4-O4
MOLECULAR WEIGHT :
1141.96

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
6700 ug/kg
TOXIC EFFECTS :
Behavioral - excitement
REFERENCE :
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 11,682,1993
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4007196
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
845 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,1114,1989

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R22;R36/37/38
Safety Phrases S26-S36
RIDADR UN 3249
WGK Germany 3
RTECS TM4569300
Packaging Group III
Hazard Class 6.1(b)

 Articles41

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A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone.

J. Clin. Psychopharmacol. 33(1) , 3-10, (2013)

The potential for iloperidone, a D2/5-HT2A antipsychotic, to affect the heart rate-corrected QT interval (QTc) was assessed in the absence and presence of metabolic inhibitors in a randomized, open-la...

Chronic angle-closure glaucoma related to paroxetine treatment.

Semin. Ophthalmol. 28(4) , 244-6, (2013)

To present a unique case of a 33-year-old woman using paroxetine who presented with acute unilateral visual loss due to chronic angle-closure glaucoma.Case report.A 33-year-old women who had been unde...

Paroxetine (Brisdelle) for hot flashes.

Med. Lett. Drugs Ther. 55(1428) , 85-6, (2013)

 Synonyms

fg7051maleate
gf74
MFCD01742665
Paroxetine maleate
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