Paroxetine maleate

Modify Date: 2024-01-13 14:55:16

Paroxetine maleate structure	Common Name	Paroxetine maleate
	CAS Number	64006-44-6	Molecular Weight	445.44
	Density	1.213 g/cm3	Boiling Point	451.7ºC at 760 mmHg
	Molecular Formula	C₂₃H₂₄FNO₇	Melting Point	136-138ºC
	MSDS	Chinese USA	Flash Point	227ºC
	Symbol	GHS07	Signal Word	Warning

Use of Paroxetine maleate

Paroxetine maleate is a potent and selective inhibitor of SSRI. Paroxetine maleate is used in generalized anxiety disorder, post traumatic stress disorder, premenstrual dysphoric disorder and chronic headache research[1].

Name	paroxetine maleate
Synonym	More Synonyms

Description	Paroxetine maleate is a potent and selective inhibitor of SSRI. Paroxetine maleate is used in generalized anxiety disorder, post traumatic stress disorder, premenstrual dysphoric disorder and chronic headache research[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter
References	[1]. Bourin M, et al. Paroxetine: a review. CNS Drug Rev. 2001 Spring;7(1):25-47.

Density	1.213 g/cm3
Boiling Point	451.7ºC at 760 mmHg
Melting Point	136-138ºC
Molecular Formula	C₂₃H₂₄FNO₇
Molecular Weight	445.44
Flash Point	227ºC
Exact Mass	445.15400
PSA	114.32000
LogP	3.36710
Storage condition	2-8°C

Paroxetine maleate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM4569300

CHEMICAL NAME :: Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl )-, trans-(-)-, (Z)-2- butenedioate

CAS REGISTRY NUMBER :: 64006-44-6

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C19-H20-F-N-O3.xC4-H4-O4

MOLECULAR WEIGHT :: 1141.96

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 6700 ug/kg

TOXIC EFFECTS :: Behavioral - excitement

REFERENCE :: AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 11,682,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4007196

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 845 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,1114,1989

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36
RIDADR	UN 3249
WGK Germany	3
RTECS	TM4569300
Packaging Group	III
Hazard Class	6.1(b)

A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone.

J. Clin. Psychopharmacol. 33(1) , 3-10, (2013)

The potential for iloperidone, a D2/5-HT2A antipsychotic, to affect the heart rate-corrected QT interval (QTc) was assessed in the absence and presence of metabolic inhibitors in a randomized, open-la...

Chronic angle-closure glaucoma related to paroxetine treatment.

Semin. Ophthalmol. 28(4) , 244-6, (2013)

To present a unique case of a 33-year-old woman using paroxetine who presented with acute unilateral visual loss due to chronic angle-closure glaucoma.Case report.A 33-year-old women who had been unde...

Paroxetine (Brisdelle) for hot flashes.

Med. Lett. Drugs Ther. 55(1428) , 85-6, (2013)

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MFCD01742665

Paroxetine maleate

DC Chemicals Limited
China
Product Name: Paroxetine maleate
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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