Histidine hydrochloride

Modify Date: 2026-07-08 14:08:06

Histidine hydrochloride Structure
Histidine hydrochloride structure
Common Name Histidine hydrochloride
CAS Number 645-35-2 Molecular Weight 191.615
Density N/A Boiling Point 458.9ºC at 760 mmHg
Molecular Formula C6H10ClN3O2 Melting Point N/A
MSDS N/A Flash Point 231.3ºC

 Names

Name (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid hydrochloride
Synonym More Synonyms

 Chemical & Physical Properties

Boiling Point 458.9ºC at 760 mmHg
Molecular Formula C6H10ClN3O2
Molecular Weight 191.615
Flash Point 231.3ºC
Exact Mass 191.046158
PSA 92.00000
LogP 0.86640
InChIKey QZNNVYOVQUKYSC-JEDNCBNOSA-N
SMILES Cl.NC(Cc1cnc[nH]1)C(=O)O
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MS3116100
CHEMICAL NAME :
Histidine, monohydrochloride, L-
CAS REGISTRY NUMBER :
645-35-2
LAST UPDATED :
199706
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C6-H9-N3-O2.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4407 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
697 gm/kg/2Y-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 34,687,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82261 No. of Facilities: 59 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 744 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82261 No. of Facilities: 196 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 2601 (estimated) No. of Female Employees: 1791 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves
Hazard Codes Xi
RIDADR UN 1789
WGK Germany 2
HS Code 2922499990

 Synthetic Route

~29%

Histidine hydrochloride Structure

Histidine hydro...

CAS#:645-35-2

Learn More
Literature: Weissbuch, I.; Zbaida, D.; Addadi, L.; Leiserowitz, L.; Lahav, M. Journal of the American Chemical Society, 1987 , vol. 109, # 6 p. 1869 - 1871

~%

Histidine hydrochloride Structure

Histidine hydro...

CAS#:645-35-2

Learn More
Literature: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, , vol. 75, # 1 p. 293 - 298

~%

Histidine hydrochloride Structure

Histidine hydro...

CAS#:645-35-2

Learn More
Literature: Molecular Crystals and Liquid Crystals (1969-1991), , vol. 161, p. 199 - 222

 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

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 Synonyms

Histidine, hydrochloride (1:1)
L-Histidine, monohydrochloride
Histidine hydrochloride (VAN)
Histidine hydrochloride (1:1)
L-Histidine hydrochloride
l-Histidine.HCl
EINECS 211-438-9
MFCD00064556
L-Histidine hydrochloride (VAN)
(-)-HISTIDINE MONOHYDROCHLORIDE
Histidine, monohydrochloride
Histidine hydrochloride
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