Phomopsin A

Modify Date: 2026-07-14 08:18:46

Phomopsin A structure	Common Name	Phomopsin A
	CAS Number	64925-80-0	Molecular Weight	789.22800
	Density	1.48g/cm3	Boiling Point	1188.2ºC at 760 mmHg
	Molecular Formula	C₃₆H₄₅ClN₆O₁₂	Melting Point	N/A
	MSDS	N/A	Flash Point	672.4ºC

Use of Phomopsin A

Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis. Phomopsin A is a noncompetitive inhibitor of the binding of radiolabeled vincristine to tubulin[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	phomopsin a
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis. Phomopsin A is a noncompetitive inhibitor of the binding of radiolabeled vincristine to tubulin[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
References	[1]. Hamel E, et al. Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B. Pharmacol Ther. 1992;55(1):31-51.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.48g/cm3
Boiling Point	1188.2ºC at 760 mmHg
Molecular Formula	C₃₆H₄₅ClN₆O₁₂
Molecular Weight	789.22800
Flash Point	672.4ºC
Exact Mass	788.27800
PSA	273.03000
LogP	2.27850
Index of Refraction	1.655
InChIKey	FAFRRYBYQKPKSY-LTHPOZSPSA-N
SMILES	C=C(C)C1NC(=O)C(NC)C(O)c2cc(Cl)c(O)c(c2)OC(C)(CC)C(C(=O)N2CC=CC2C(=O)NC(C(=O)NC(=CC(=O)O)C(=O)O)=C(C)CC)NC1=O

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SY2593000

CHEMICAL NAME :: Phomopsin A

CAS REGISTRY NUMBER :: 64925-80-0

LAST UPDATED :: 199801

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 10 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 1 mg/kg/1W-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Liver - other changes Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 1 mg/kg/4W-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Liver - jaundice (or hyperbilirubinemia) hepatocellular

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 150 ug/kg

SEX/DURATION :: female 6-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 400 ug/kg

SEX/DURATION :: female 6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 10 mg/L

REFERENCE :: CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 46,79,1986

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes	Xn: Harmful;
Risk Phrases	20/21/22-40

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

phomopsin a from phomopsis leptostromiformis

phomopsin

PMSA

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular formula of phomopsin a?

A: Molecular formula of phomopsin a is C36H45ClN6O12.

Q: What is the English name of phomopsin a?

A: The English name of phomopsin a is phomopsin a.

Q: What is the boiling point of phomopsin a?

A: Boiling point of phomopsin a is 1188.2ºC at 760 mmHg.

Q: What English synonyms does phomopsin a have?

A: English synonyms of phomopsin a: phomopsin a from phomopsis leptostromiformis, phomopsin, PMSA.

Q: What is the polar surface area (PSA) of phomopsin a?

A: Polar surface area (PSA) of phomopsin a is 273.03000.

Q: What is the LogP of phomopsin a?

A: LogP of phomopsin a is 2.27850.

Q: What is the InChIKey of phomopsin a?

A: InChIKey of phomopsin a is FAFRRYBYQKPKSY-LTHPOZSPSA-N.

Q: What is the SMILES notation of phomopsin a?

A: SMILES notation of phomopsin a is C=C(C)C1NC(=O)C(NC)C(O)c2cc(Cl)c(O)c(c2)OC(C)(CC)C(C(=O)N2CC=CC2C(=O)NC(C(=O)NC(=CC(=O)O)C(=O)O)=C(C)CC)NC1=O.

Q: What is the CAS number of phomopsin a?

A: CAS number of phomopsin a is 64925-80-0.

Q: What are the uses of phomopsin a?

A: Main uses of phomopsin a: Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis. Phomopsin A is a noncompetitive inhibitor of the binding of radiolabeled vincristine to tubulin[1].

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Phomopsin A

Use of Phomopsin A

Names

Phomopsin A Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synonyms

Phomopsin A | FAQ

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.