Cefmenoxime
Modify Date: 2026-07-03 22:21:50
Cefmenoxime structure
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Common Name | Cefmenoxime | ||
|---|---|---|---|---|
| CAS Number | 65085-01-0 | Molecular Weight | 511.55800 | |
| Density | 1.96 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C16H17N9O5S3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CefmenoximeCefmenoxime (SCE-1365) is a new semisynthetic cephalosporin antibiotic. Cefmenoxime has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria[1][2]. |
| Name | cefmenoxime |
|---|---|
| Synonym | More Synonyms |
| Description | Cefmenoxime (SCE-1365) is a new semisynthetic cephalosporin antibiotic. Cefmenoxime has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria[1][2]. |
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| Related Catalog | |
| In Vitro | Cefmenoxime (SCE-1365) inhibits at least 90% of strains tested (MIC90) ranged from 0.06 to 8 μg/mL for the Enterobacteriaceae[1]. Cefmenoxime (SCE-1365) inhibits MIC90 values for gram-positive cocci are 0.015 and ≤0.008 μg/mL for Streptococcus pneumoniae and Streptococcus pyogenes, respectively, and 2 μg/mL for S. aureus[1]. Cefmenoxime (SCE-1365) against Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis with MIC90 values ranging from ≤0.008 to 0.25 μg/mL[1]. |
| In Vivo | Cefmenoxime (SCE-1365) (40 mg/kg; i.h.; daily, for 7 d; male Jcl:ICR mice) improves the survival rate of mice infected with lung bacteria[2]. Animal Model: Male Jcl:ICR mice[2] Dosage: 40 mg/kg Administration: Subcutaneous injection; daily, for 7 days Result: Inhibited mortality rate of animals was 60% at a dose of 40 mg/kg. |
| References |
| Density | 1.96 g/cm3 |
|---|---|
| Molecular Formula | C16H17N9O5S3 |
| Molecular Weight | 511.55800 |
| Exact Mass | 511.05100 |
| PSA | 269.65000 |
| LogP | 0.04020 |
| InChIKey | HJJDBAOLQAWBMH-NOZJJQNGSA-N |
| SMILES | CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(CSc3nnnn3C)CSC12)c1csc(N)n1 |
| Hazard Codes | Xi |
|---|---|
| Risk Phrases | R41:Risk of serious damage to eyes. |
| Safety Phrases | S26-S39 |
| Precursor 1 | |
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| DownStream 0 | |
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| Cefmenoxime |
| 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,(6R,7R) |
| (6R,7R)-7-[[(Z)-(2-Aminothiazol-4-yl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| SCE 1365 |
| 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[[1-methyl-1H-tetrazol-5-yl]thiomethyl]-3-cephem-4-carboxylic acid |
| MFCD00864851 |
| CMX |