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Product Name: Cefmenoxime
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65085-01-0

65085-01-0 structure

65085-01-0 structure

Name: Cefmenoxime
Chemical Name: cefmenoxime
CAS Number: 65085-01-0
Molecular Formula: C₁₆H₁₇N₉O₅S₃
Molecular Weight: 511.55800
Catalog: API Antibiotics Cephalosporin
Create Date: 2018-06-10 11:18:10
Modify Date: 2026-07-03 22:21:50
Cefmenoxime (SCE-1365) is a new semisynthetic cephalosporin antibiotic. Cefmenoxime has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria[1][2].

Name	cefmenoxime
Synonyms	(6R,7R)-7-[[(Z)-(2-Aminothiazol-4-yl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid (6r-(6alpha,7beta(z)))-7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-cboxylic acid (6R,7R)-7α-[2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetylamino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid 7β-[[(Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazole-5-yl)thio]methyl]cham-3-ene-4-cboxylic acid Cefotaxime Isomer (6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid (6R,7R)-7-[[(Z)-(2-Aminothiazol-4-yl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid CEFMENOXIME 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R) 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, [6R-[6α,7β(Z)]] Cefmenoxime //BP [6R-[6α，7β(Z)]]-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-y1)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oet-2-ene-2-cboxylic acid CMX (6R,7R)-7-[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(MethoxyiMino)acetaMido]-3-{[(1-Methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]Methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R) 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,(6R,7R) SCE 1365 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[[1-methyl-1H-tetrazol-5-yl]thiomethyl]-3-cephem-4-carboxylic acid MFCD00864851

Description	Cefmenoxime (SCE-1365) is a new semisynthetic cephalosporin antibiotic. Cefmenoxime has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Cefmenoxime (SCE-1365) inhibits at least 90% of strains tested (MIC90) ranged from 0.06 to 8 μg/mL for the Enterobacteriaceae[1]. Cefmenoxime (SCE-1365) inhibits MIC90 values for gram-positive cocci are 0.015 and ≤0.008 μg/mL for Streptococcus pneumoniae and Streptococcus pyogenes, respectively, and 2 μg/mL for S. aureus[1]. Cefmenoxime (SCE-1365) against Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis with MIC90 values ranging from ≤0.008 to 0.25 μg/mL[1].
In Vivo	Cefmenoxime (SCE-1365) (40 mg/kg; i.h.; daily, for 7 d; male Jcl:ICR mice) improves the survival rate of mice infected with lung bacteria[2]. Animal Model: Male Jcl:ICR mice[2] Dosage: 40 mg/kg Administration: Subcutaneous injection; daily, for 7 days Result: Inhibited mortality rate of animals was 60% at a dose of 40 mg/kg.
References	[1]. Stamm JM, et, al. Antimicrobial activity of cefmenoxime (SCE-1365). Antimicrob Agents Chemother. 1981 Mar;19(3):454-60. [2]. Tatara O, et, al. Synergistic effects of romurtide and cefmenoxime against experimental Klebsiella pneumonia in mice. Antimicrob Agents Chemother. 1992 Jan;36(1):167-71.

Density	1.96 g/cm3
Molecular Formula	C₁₆H₁₇N₉O₅S₃
Molecular Weight	511.55800
Exact Mass	511.05100
PSA	269.65000
LogP	0.04020

Hazard Codes	Xi
Risk Phrases	R41:Risk of serious damage to eyes.
Safety Phrases	S26-S39

Precursor 1
24209-38-9
DownStream 0

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