3-amino-2-chloro-6-(trifluoromethyl)pyridine

Modify Date: 2024-01-14 17:19:45

3-amino-2-chloro-6-(trifluoromethyl)pyridine Structure
3-amino-2-chloro-6-(trifluoromethyl)pyridine structure
Common Name 3-amino-2-chloro-6-(trifluoromethyl)pyridine
CAS Number 65182-56-1 Molecular Weight 222.24200
Density N/A Boiling Point N/A
Molecular Formula C14H10N2O Melting Point 92-94ºC
MSDS Chinese USA Flash Point N/A
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Use of 3-amino-2-chloro-6-(trifluoromethyl)pyridine


2-NP is a selective enhancer of STAT1 transcription. 2-NP can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells[1].

 Names

Name 6-(1H-1,8-naphthyridin-2-ylidene)cyclohexa-2,4-dien-1-one
Synonym More Synonyms

  Biological Activity

Description 2-NP is a selective enhancer of STAT1 transcription. 2-NP can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells[1].
Related Catalog
References

[1]. Lynch RA, et, al. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. Cancer Res. 2007 Feb 1;67(3):1254-61.

 Chemical & Physical Properties

Melting Point 92-94ºC
Molecular Formula C14H10N2O
Molecular Weight 222.24200
Exact Mass 222.07900
PSA 46.01000
LogP 3.00240
Appearance of Characters orange
Storage condition room temp
Water Solubility DMSO: ≥10mg/mL

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302-H318
Precautionary Statements P280-P305 + P351 + P338
Hazard Codes Xn,T
Risk Phrases 22-41-36-25
Safety Phrases 26-39-45
RIDADR NONH for all modes of transport
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

2-<o-Hydroxy-phenyl>-1,8-naphthyridin