Gossypin

Modify Date: 2025-08-23 19:33:54

Gossypin structure	Common Name	Gossypin
	CAS Number	652-78-8	Molecular Weight	480.37600
	Density	1.883 g/cm3	Boiling Point	886ºC at 760 mmHg
	Molecular Formula	C₂₁H₂₀O₁₃	Melting Point	229-230ºC
	MSDS	Chinese USA	Flash Point	310.8ºC
	Symbol	GHS07	Signal Word	Warning

Use of Gossypin

Gossypin is a flavone isolated from Hibiscus vitifolius and has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, analgesic and hepatoprotective activities. Gossypin inhibits NF-κB and NF-κB-regulated gene expression. Gossypin inhibits RANKL-induced osteoclastogenesis both in mouse primary bone marrow cells and RAW 264.7 cells in vitro[1][2].

Name	gossypin
Synonym	More Synonyms

Description	Gossypin is a flavone isolated from Hibiscus vitifolius and has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, analgesic and hepatoprotective activities. Gossypin inhibits NF-κB and NF-κB-regulated gene expression. Gossypin inhibits RANKL-induced osteoclastogenesis both in mouse primary bone marrow cells and RAW 264.7 cells in vitro[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology
Target	IC50: NF-κB[1]
References	[1]. Ajaikumar B Kunnumakkara, et al. Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. Blood. 2007 Jun 15;109(12):5112-21. [2]. Kanika Patel, et al. Gossypin: A phytochemical of multispectrum potential. the Journal of Coastal Life Medicine.

Density	1.883 g/cm3
Boiling Point	886ºC at 760 mmHg
Melting Point	229-230ºC
Molecular Formula	C₂₁H₂₀O₁₃
Molecular Weight	480.37600
Flash Point	310.8ºC
Exact Mass	480.09000
PSA	230.74000
Index of Refraction	1.799
InChIKey	SJRXVLUZMMDCNG-KKPQBLLMSA-N
SMILES	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2c(OC3OC(CO)C(O)C(O)C3O)c(O)cc(O)c12

Gossypin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3009900

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-(beta-D-glucopyranosyloxy)- 3,5,7- trihydroxy-

CAS REGISTRY NUMBER :: 652-78-8

BEILSTEIN REFERENCE NO. :: 0071526

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H20-O13

MOLECULAR WEIGHT :: 480.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2240 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)- Volume(issue)/page/year: 10,277,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,647,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 26300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,647,1959

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36-37
RIDADR	NONH for all modes of transport

Impact of polyphenolic components from mulberry on apoptosis of vascular smooth muscle cells.

J. Sci. Food Agric. 96 , 381-91, (2015)

Previous studies have shown that mulberry polyphenolic compounds have an anti-atherosclerotic effect in rabbits. Apoptosis of vascular smooth muscle cells (VSMCs) is the key determinant of the number ...

Name: Inhibition of NF-kappaB activation expressed in HCT116 cells assessed as inhibition o...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1839570

Name: Aurora B Kinase Assay from Article 10.1111/cbdd.12445: "Plant-derived flavones as inh...
Source: BindingDB
Target: N/A
External Id: BindingDB_6826_1

Name: Inhibition of human liver FBP1 at 200 uM incubated for 5 mins by fluorescence method ...
Source: ChEMBL
Target: Fructose-1,6-bisphosphatase 1
External Id: CHEMBL4629675

Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS

Name: Binding affinity to human CDK2
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL928948

Name: HIV Enzyme Data
Source: NIAID
Target: N/A
External Id: HIV Enzyme Data

Name: Antioxidant activity assessed as DPPH free radical scavenging activity
Source: ChEMBL
Target: N/A
External Id: CHEMBL1826758

Name: HIV Cellular Data
Source: NIAID
Target: N/A
External Id: HIV Cellular Data

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Gossypetin 8-O-glucoside

3,5,7,8,3',4'-hexahydroxyflavone-8-O-glucopyranoside

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one

3,3',4',5,7-pentahydroxyflavone-8-O-glucoside

Gossypin

Gossypetin-8-glucoside

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Gossypin

Use of Gossypin

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MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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GossypinBioassay

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