(S)-(+)-N,N-DIMETHYL-3-(1-NAPHTHALENYLOXY)-3-(2-THIENYL)PROPANAMINE

Modify Date: 2024-01-04 22:19:18

(S)-(+)-N,N-DIMETHYL-3-(1-NAPHTHALENYLOXY)-3-(2-THIENYL)PROPANAMINE structure	Common Name	(S)-(+)-N,N-DIMETHYL-3-(1-NAPHTHALENYLOXY)-3-(2-THIENYL)PROPANAMINE
	CAS Number	65567-34-2	Molecular Weight	204.22500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₁₂N₂O₂	Melting Point	195-200ºC
	MSDS	USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Name	(s)-(+)-nirvanol

Melting Point	195-200ºC
Molecular Formula	C₁₁H₁₂N₂O₂
Molecular Weight	204.22500
Exact Mass	204.09000
PSA	58.20000
LogP	1.78890
Appearance of Characters	off-white
Storage condition	2-8°C
Water Solubility	DMF: soluble

MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MU2452120

CHEMICAL NAME :: Hydantoin, 5-ethyl-5-phenyl-, (+)-

CAS REGISTRY NUMBER :: 65567-34-2

BEILSTEIN REFERENCE NO. :: 0085311

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C11-H12-N2-O2

MOLECULAR WEIGHT :: 204.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Skin and Appendages - dermatitis, allergic (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 47,209,1933

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BBIADT Biomedica Biochimica Acta. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.42- 1983- Volume(issue)/page/year: 46,623,1987

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 175 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 47,209,1933

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 47,209,1933

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn,Xi
Risk Phrases	22-36/37/38-20/21/22
Safety Phrases	26-37/39-36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	MU2452000
HS Code	2933990090

Precursor 6
CAS#:2216-93-5 2,4-Imidazolidi... CAS#:5438-07-3 2-AMINO-2-PHENY... CAS#:52247-77-5 (S)-(+)-2-(DIBE... CAS#:33875-36-4 2-isocyanato-2-...
CAS#:57-13-6 Urea CAS#:70989-04-7 (S)-Mephenytoin
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Pharmacodynamics of cytochrome P450 2B induction by phenobarbital, 5-ethyl-5-phenylhydantoin, and 5-ethyl-5-phenyloxazolidinedione in the male rat liver or in cultured rat hepatocytes.

Chem. Res. Toxicol. 6(2) , 188-96, (1993)

The pharmacodynamics of rat hepatic cytochrome P450 2B (P450 2B) induction by phenobarbital (PB) and two structural congeners, dl-5-ethyl-5-phenylhydantoin (EPH) and dl-5-ethyl-5-phenyloxazolidinedion...

A markedly diminished pleiotropic response to phenobarbital and structurally-related xenobiotics in Zucker rats in comparison with F344/NCr or DA rats.

Biochem. Pharmacol. 43(5) , 1079-87, (1992)

Phenobarbital (PB) and certain structurally-related compounds induce a variety of hepatic drug-metabolizing enzymes in many strains of rats. Thus, following administration of PB (300, 500 ppm), barbit...

Active-site characteristics of CYP2C19 and CYP2C9 probed with hydantoin and barbiturate inhibitors.

Arch. Biochem. Biophys. 429(1) , 1-15, (2004)

Three series of N-3 alkyl substituted phenytoin, nirvanol, and barbiturate derivatives were synthesized and their inhibitor potencies were tested against recombinant CYP2C19 and CYP2C9 to probe the in...

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (S)-(+)-Nirvanol
Price: Click To Check
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (S)-(+)-N,N-DIMETHYL-3-(1-NAPHTHALENYLOXY)-3-(2-THIENYL)PROPANAMINE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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(S)-(+)-N,N-DIMETHYL-3-(1-NAPHTHALENYLOXY)-3-(2-THIENYL)PROPANAMINE

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