Bis-ANS dipotassium
Bis-ANS dipotassium structure
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Common Name | Bis-ANS dipotassium | ||
|---|---|---|---|---|
| CAS Number | 65664-81-5 | Molecular Weight | 672.85300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H22K2N2O6S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Bis-ANS dipotassiumBis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM[1]. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations[2]. |
| Name | Bis-ANS,4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt |
|---|---|
| Synonym | More Synonyms |
| Description | Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM[1]. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations[2]. |
|---|---|
| Related Catalog | |
| In Vitro | Bis-ANS is a fluorescent molecule that has been used to probe exposed hydrophobic patches in proteins and to monitor the formation of protein aggregates. Bis-ANS is a bivalent naphthalene sulfonate with aniline moieties. Bis-ANS modulates the liquid-liquid phase separation of TDP-43 low complexity domain (LCD)[2]. |
| References |
| Molecular Formula | C32H22K2N2O6S2 |
|---|---|
| Molecular Weight | 672.85300 |
| Exact Mass | 672.01900 |
| PSA | 155.22000 |
| LogP | 9.26300 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H315-H319-H332-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | R20/21/22;R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
|
~29%
Bis-ANS dipotassium CAS#:65664-81-5 |
| Literature: Hornback, Joseph M.; Gossage, Henry E. Journal of Organic Chemistry, 1985 , vol. 50, # 4 p. 541 - 543 |
| Precursor 1 | |
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| DownStream 0 | |
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Interaction of ATP with a small heat shock protein from Mycobacterium leprae: effect on its structure and function.
PLoS Negl. Trop. Dis. 9(3) , e0003661, (2015) Adenosine-5'-triphosphate (ATP) is an important phosphate metabolite abundantly found in Mycobacterium leprae bacilli. This pathogen does not derive ATP from its host but has its own mechanism for the... |
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Bis(8-anilinonaphthalene-1-sulfonate) as a probe for tubulin decay.
Biochemistry 25 , 739, (1986) The fluorescent apolar probe bis(8-anilinonaphthalene-1-sulfonate) (Bis-ANS) has been used to detect structural correlates of the well-known but poorly understood decay of tubulin function, by which t... |
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Cooperative effects in binding by bovine serum albumin. I. The binding of 1-anilino-8-naphthalenesulfonate. Fluorimetric titrations.
Biochemistry 5 , 1893, (1966)
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| BIS-ANS |
| BIS-ANS DIPOTASSIUM SALT |
| 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt |
| 4,4'-DIANILINO-1,1'-BINAPHTHYL-5,5'-DISULFONIC ACID,POTASSIUM SALT |
| potassium 8,8'-dianilino-5,5'-binaphthalene-1,1'-disulfonate |
| 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid,dipot |
| 8-Anilino-1-naphthalenesulfonic Acid Di |
| 4,4'-dianilino-1,1'-binaphthyl-5,5'-di-sulfonic A |
| 4,4'-DIANILINO-1,1'-BINAPHTHYL-5,5'-DISU LFONIC ACI |
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