Bis-ANS dipotassium

Modify Date: 2024-01-02 09:23:06

Bis-ANS dipotassium structure	Common Name	Bis-ANS dipotassium
	CAS Number	65664-81-5	Molecular Weight	672.85300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₂H₂₂K₂N₂O₆S₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of Bis-ANS dipotassium

Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM[1]. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations[2].

Name	Bis-ANS,4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt
Synonym	More Synonyms

Description	Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM[1]. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations[2].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Neurological Disease
In Vitro	Bis-ANS is a fluorescent molecule that has been used to probe exposed hydrophobic patches in proteins and to monitor the formation of protein aggregates. Bis-ANS is a bivalent naphthalene sulfonate with aniline moieties. Bis-ANS modulates the liquid-liquid phase separation of TDP-43 low complexity domain (LCD)[2].
References	[1]. P Horowitz, et al. Bis(1,8-anilinonaphthalenesulfonate). A novel and potent inhibitor of microtubule assembly. J Biol Chem. 1984 Dec 10;259(23):14647-50. [2]. W. Michael Babinchak, et al. Small molecules as potent biphasic modulators of protein liquid-liquid phase separation. Nature Communications volume 11, Article number: 5574 (2020)

Molecular Formula	C₃₂H₂₂K₂N₂O₆S₂
Molecular Weight	672.85300
Exact Mass	672.01900
PSA	155.22000
LogP	9.26300

Bis-ANS dipotassium MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H315-H319-H332-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	R20/21/22;R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport

1-ANILINONAPHTH...

CAS#:28836-03-5

~29%

Bis-ANS dipotassium

CAS#:65664-81-5

Literature: Hornback, Joseph M.; Gossage, Henry E. Journal of Organic Chemistry, 1985 , vol. 50, # 4 p. 541 - 543

Precursor 1
CAS#:28836-03-5 1-ANILINONAPHTH...
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Bis(8-anilinonaphthalene-1-sulfonate) as a probe for tubulin decay.

Biochemistry 25 , 739, (1986)

The fluorescent apolar probe bis(8-anilinonaphthalene-1-sulfonate) (Bis-ANS) has been used to detect structural correlates of the well-known but poorly understood decay of tubulin function, by which t...

Cooperative effects in binding by bovine serum albumin. I. The binding of 1-anilino-8-naphthalenesulfonate. Fluorimetric titrations.

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