GW542573X

Modify Date: 2024-01-02 12:25:03

GW542573X Structure
GW542573X structure
Common Name GW542573X
CAS Number 660846-41-3 Molecular Weight 364.44
Density N/A Boiling Point N/A
Molecular Formula C19H28N2O5 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS09
GHS09
Signal Word Warning

 Use of GW542573X


GW542573X is a potent and selective Ca2+-activated K+ 2 (SK2) channels activator. GW542573X induces the Ca2+-response curve of hSK1 that left-shifted from an EC50 (Ca2+) value of 410 nM to 240 nM[1].

 Names

Name 2-Methyl-2-propanyl 4-({[(2-methoxyphenyl)carbamoyl]oxy}methyl)-1 -piperidinecarboxylate
Synonym More Synonyms

 GW542573X Biological Activity

Description GW542573X is a potent and selective Ca2+-activated K+ 2 (SK2) channels activator. GW542573X induces the Ca2+-response curve of hSK1 that left-shifted from an EC50 (Ca2+) value of 410 nM to 240 nM[1].
Related Catalog
References

[1]. Hougaard C, et, al. Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment. Mol Pharmacol. 2009 Sep;76(3):569-78.  

 Chemical & Physical Properties

Molecular Formula C19H28N2O5
Molecular Weight 364.44
Exact Mass 364.20000
PSA 80.59000
LogP 3.84230

 Safety Information

Symbol GHS09
GHS09
Signal Word Warning
Hazard Statements H410
Precautionary Statements P273-P501
RIDADR UN 3077 9 / PGIII

 Synonyms

DAU 5884 hydrochloride
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