RU 24969 hemisuccinate
Modify Date: 2024-01-14 19:06:34
RU 24969 hemisuccinate structure
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Common Name | RU 24969 hemisuccinate | ||
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| CAS Number | 66611-27-6 | Molecular Weight | 574.667 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H38N4O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RU 24969 hemisuccinateRU 24969 hemisuccinate is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion[1]. |
| Name | 5-Methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole succinate (2:1) |
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| Synonym | More Synonyms |
| Description | RU 24969 hemisuccinate is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion[1]. |
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| Related Catalog | |
| Target |
5-HT1B Receptor:0.38 nM (Ki) 5-HT1A Receptor:2.5 nM (Ki) |
| In Vitro | RU 24969 (10 μM) reduces K+-stimulated release of [3H]-5-HT from ratfrontalcortex slices in vitro[2]. |
| In Vivo | RU 24969 (0.03-3.0 mg/kg; s.c.) dose-dependently decreases water consumption in water deprived rats[1]. RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 0.03, 0.3, 1.0, 3.0 mg/kg Administration: A single s.c. Result: Decreased water consumption significantly at dose of 0.3, 1.0, and 3.0 mg/kg. |
| References |
| Molecular Formula | C32H38N4O6 |
|---|---|
| Molecular Weight | 574.667 |
| Exact Mass | 574.279114 |
| 5-Methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole succinate (2:1) |
| MFCD09878262 |
| 1H-Indole, 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-, butanedioate (2:1) |
| Succinic acid - 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (1:2) |