6-Monohydroxyflavone

Modify Date: 2025-08-23 12:52:36

6-Monohydroxyflavone Structure
6-Monohydroxyflavone structure
 Common Name 6-Monohydroxyflavone
CAS Number 6665-83-4 Molecular Weight 238.238
Density 1.3±0.1 g/cm3 Boiling Point 450.1±45.0 °C at 760 mmHg
Molecular Formula C15H10O3 Melting Point 234-236 °C(lit.)
MSDS N/A Flash Point 176.3±22.2 °C

 Use of 6-Monohydroxyflavone


6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2].

 Names

Name 6-Hydroxyflavone
Synonym More Synonyms

 6-Monohydroxyflavone Biological Activity

Description 6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2].
Related Catalog
References

[1]. Das S, et al. Characterization of non-covalent binding of 6-hydroxyflavone and 5,7-dihydroxyflavone with bovine hemoglobin: Multi-spectroscopic and molecular docking analyses. J Photochem Photobiol B. 2018 Jan;178:40-52.

[2]. Lai CH, et al. Effects of 6-Hydroxyflavone on Osteoblast Differentiation in MC3T3-E1 Cells. Evid Based Complement Alternat Med. 2014;2014:924560.

[3]. Wang X, et al. 6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylated flavones in kidney mesangial cells. PLoS One. 2015 Mar 19;10(3):e0116409.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 450.1±45.0 °C at 760 mmHg
Melting Point 234-236 °C(lit.)
Molecular Formula C15H10O3
Molecular Weight 238.238
Flash Point 176.3±22.2 °C
Exact Mass 238.062988
PSA 50.44000
LogP 3.72
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.666
InChIKey GPZYYYGYCRFPBU-UHFFFAOYSA-N
SMILES O=c1cc(-c2ccccc2)oc2ccc(O)cc12

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
WGK Germany 3
HS Code 2914400090

 Synthetic Route

 Customs

HS Code 2914400090
Summary 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 6-MonohydroxyflavoneBioassay

View more

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: Antioxidant activity against toxin solution-induced lipid peroxidation in Sprague-Daw...
Source: ChEMBL
Target: Brain
External Id: CHEMBL1936125
Name: Antioxidant activity assessed as ferric ion reducing activity using fe3+-TPTZ at 1 mM...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1936124
Name: Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ...
Source: ChEMBL
Target: Klebsiella pneumoniae
External Id: CHEMBL4296186
Name: Antioxidant activity against toxin solution-induced lipid peroxidation in Sprague-Daw...
Source: ChEMBL
Target: Brain
External Id: CHEMBL1936127
Name: Antioxidant activity against toxin solution-induced lipid peroxidation in Sprague-Daw...
Source: ChEMBL
Target: Brain
External Id: CHEMBL1936126
Name: Antioxidant activity against toxin solution-induced lipid peroxidation in Sprague-Daw...
Source: ChEMBL
Target: Brain
External Id: CHEMBL1936128
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
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 Synonyms

EINECS 229-704-8
6-Monohydroxyflavone
MFCD00017329
6-hydroxy-2-phenylchromen-4-one
6-Hydroxy-2-phenyl-4H-chromen-4-one
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Price: ￥550/10 mM * 1 mL in DMSO

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Chemsrc provides 6-Monohydroxyflavone(CAS#:6665-83-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 6-Monohydroxyflavone are included as well.>> amp version: 6-Monohydroxyflavone

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