MeBIO
MeBIO structure
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Common Name | MeBIO | ||
|---|---|---|---|---|
| CAS Number | 667463-95-8 | Molecular Weight | 370.20 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H12BrN3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MeBIOMeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC50 of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively. MeBIO is inactive on GSK-3β[1]. |
| Name | 6-bromo-3-[3-(hydroxyamino)indol-2-ylidene]-1-methylindol-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC50 of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively. MeBIO is inactive on GSK-3β[1]. |
|---|---|
| Related Catalog | |
| Target |
GSK-3:44 μM (IC50) Cdk1/cyclin B:55 μM (IC50) Cdk5/p25:>100 μM (IC50) |
| References |
| Molecular Formula | C17H12BrN3O2 |
|---|---|
| Molecular Weight | 370.20 |
| Exact Mass | 369.01100 |
| PSA | 64.93000 |
| LogP | 1.44850 |
| Storage condition | -20°C |
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MeBIO CAS#:667463-95-8 |
| Literature: Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946 |
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MeBIO CAS#:667463-95-8 |
| Literature: Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946 |
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MeBIO CAS#:667463-95-8 |
| Literature: Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946 |
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MeBIO CAS#:667463-95-8 |
| Literature: Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946 |
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MeBIO CAS#:667463-95-8 |
| Literature: Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946 |
| methyl-6BIO |
| 6-bromo-1-methylindirubin-3'-oxime |
| IN1310 |