MeBIO

Modify Date: 2025-08-22 13:09:04

MeBIO Structure
MeBIO structure
 Common Name MeBIO
CAS Number 667463-95-8 Molecular Weight 370.20
Density N/A Boiling Point N/A
Molecular Formula C17H12BrN3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MeBIO


MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC50 of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively. MeBIO is inactive on GSK-3β[1].

 Names

Name 6-bromo-3-[3-(hydroxyamino)indol-2-ylidene]-1-methylindol-2-one
Synonym More Synonyms

 MeBIO Biological Activity

Description MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC50 of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively. MeBIO is inactive on GSK-3β[1].
Related Catalog
Target

GSK-3:44 μM (IC50)

Cdk1/cyclin B:55 μM (IC50)

Cdk5/p25:>100 μM (IC50)

References

[1]. Meijer L, et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10(12):1255-66.

 Chemical & Physical Properties

Molecular Formula C17H12BrN3O2
Molecular Weight 370.20
Exact Mass 369.01100
PSA 64.93000
LogP 1.44850
Storage condition -20°C

 Synthetic Route

1-Methyl-6-bromoindirubin structure

1-Methyl-6-brom...

CAS#:667463-98-1

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MeBIO Structure

MeBIO

CAS#:667463-95-8

Literature: Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946
6-Bromoisatin structure

6-Bromoisatin

CAS#:6326-79-0

~%

MeBIO Structure

MeBIO

CAS#:667463-95-8

Literature: Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946
6-Bromo-1-Methylisatin structure

6-Bromo-1-Methy...

CAS#:667463-64-1

~%

MeBIO Structure

MeBIO

CAS#:667463-95-8

Literature: Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946
3-Bromoaniline structure

3-Bromoaniline

CAS#:591-19-5

~%

MeBIO Structure

MeBIO

CAS#:667463-95-8

Literature: Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946
N-(3-bromophenyl)-2-hydroxyiminoacetamide structure

N-(3-bromopheny...

CAS#:65971-74-6

~%

MeBIO Structure

MeBIO

CAS#:667463-95-8

Literature: Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946

 Synonyms

methyl-6BIO
6-bromo-1-methylindirubin-3'-oxime
IN1310
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Chemsrc provides MeBIO(CAS#:667463-95-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of MeBIO are included as well.>> amp version: MeBIO

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