667463-95-8
667463-95-8 structure
- Name: MeBIO
- Chemical Name: 6-bromo-3-[3-(hydroxyamino)indol-2-ylidene]-1-methylindol-2-one
- CAS Number: 667463-95-8
- Molecular Formula: C17H12BrN3O2
- Molecular Weight: 370.20
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2016-02-10 14:42:16
- Modify Date: 2024-01-25 00:31:13
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MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC50 of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively. MeBIO is inactive on GSK-3β[1].
| Name | 6-bromo-3-[3-(hydroxyamino)indol-2-ylidene]-1-methylindol-2-one |
|---|---|
| Synonyms |
methyl-6BIO
6-bromo-1-methylindirubin-3'-oxime IN1310 |
| Description | MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC50 of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively. MeBIO is inactive on GSK-3β[1]. |
|---|---|
| Related Catalog | |
| Target |
GSK-3:44 μM (IC50) Cdk1/cyclin B:55 μM (IC50) Cdk5/p25:>100 μM (IC50) |
| References |
| Molecular Formula | C17H12BrN3O2 |
|---|---|
| Molecular Weight | 370.20 |
| Exact Mass | 369.01100 |
| PSA | 64.93000 |
| LogP | 1.44850 |
| Storage condition | -20°C |
|
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667463-95-8 |
| Literature: Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946 |
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667463-95-8 |
| Literature: Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946 |
|
~%
667463-95-8 |
| Literature: Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946 |
|
~%
667463-95-8 |
| Literature: Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946 |
|
~%
667463-95-8 |
| Literature: Polychronopoulos, Panagiotis; Magiatis, Prokopios; Skaltsounis, Alexios-Leandros; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Tarricone, Aldo; Musacchio, Andrea; Roe, S. Mark; Pearl, Laurence; Leost, Maryse; Greengard, Paul; Meijer, Laurent Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 935 - 946 |
| Precursor 5 | |
|---|---|
| DownStream 0 | |