Thiamine Disulfide Hydrate
Modify Date: 2025-08-25 16:33:58
Thiamine Disulfide Hydrate structure
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Common Name | Thiamine Disulfide Hydrate | ||
|---|---|---|---|---|
| CAS Number | 67-16-3 | Molecular Weight | 562.708 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 886.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C24H34N8O4S2 | Melting Point | 177ºC | |
| MSDS | N/A | Flash Point | 489.7±34.3 °C | |
Use of Thiamine Disulfide HydrateThiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity[1][2]. |
| Name | Thiamine Disulfide Hydrate |
|---|---|
| Synonym | More Synonyms |
| Description | Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Thiamine disulfide markedly inhibits production of progeny HIV-1 in acute and chronic HIV-1-infected CEM at nontoxic concentrations of 500-1000 μM. Thiamine disulfide (500 μM) blocks 99.7% of HIV-1 production after 96 hours culture in acute HIV-1 (LAV-1) infection, whereas it inhibits 90-98% of HIV-1 production in chronic-infected cells (CEM/LAV-1, H9/MN, and Molt-4/IIIB)[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 886.1±65.0 °C at 760 mmHg |
| Melting Point | 177ºC |
| Molecular Formula | C24H34N8O4S2 |
| Molecular Weight | 562.708 |
| Flash Point | 489.7±34.3 °C |
| Exact Mass | 562.214417 |
| PSA | 235.28000 |
| LogP | 2.79 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.669 |
| RTECS | LQ2715000 |
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Thiamine Disulf... CAS#:67-16-3 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 38, # 7 p. 1819 - 1823 |
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Thiamine Disulf... CAS#:67-16-3 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 38, # 7 p. 1819 - 1823 |
| Precursor 2 | |
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| DownStream 1 | |
CAS#:490-82-4| Formamide, N,N'-[dithiobis[(Z)-2-(2-hydroxyethyl)-1-methyl-2,1-ethenediyl]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]- |
| MFCD00010427 |
| Thiamine Disulfide |
| Vitamin B1 Disulfide |
| EINECS 200-644-4 |
| Aneurine Disulfide |
| AKTIVIN |
| N,N'-{Disulfanediylbis[(2Z)-5-hydroxypent-2-ene-3,2-diyl]}bis{N-[(4-amino-2-methylpyrimidin-5-yl)methyl]formamide} |
| N,N'-{Disulfanediylbis[(2Z)-5-hydroxy-2-pentene-3,2-diyl]}bis{N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamide} |