Thiamine Disulfide Hydrate

Modify Date: 2024-01-03 07:23:43

Thiamine Disulfide Hydrate Structure
Thiamine Disulfide Hydrate structure
 Common Name Thiamine Disulfide Hydrate
CAS Number 67-16-3 Molecular Weight 562.708
Density 1.4±0.1 g/cm3 Boiling Point 886.1±65.0 °C at 760 mmHg
Molecular Formula C24H34N8O4S2 Melting Point 177ºC
MSDS N/A Flash Point 489.7±34.3 °C

 Use of Thiamine Disulfide Hydrate


Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity[1][2].

 Names

Name Thiamine Disulfide Hydrate
Synonym More Synonyms

 Thiamine Disulfide Hydrate Biological Activity

Description Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity[1][2].
Related Catalog
In Vitro Thiamine disulfide markedly inhibits production of progeny HIV-1 in acute and chronic HIV-1-infected CEM at nontoxic concentrations of 500-1000 μM. Thiamine disulfide (500 μM) blocks 99.7% of HIV-1 production after 96 hours culture in acute HIV-1 (LAV-1) infection, whereas it inhibits 90-98% of HIV-1 production in chronic-infected cells (CEM/LAV-1, H9/MN, and Molt-4/IIIB)[1].
References

[1]. S Shoji, et al. Thiamine disulfide as a potent inhibitor of human immunodeficiency virus (type-1) production. Biochem Biophys Res Commun. 1994 Nov 30;205(1):967-75.

[2]. Y Komata, et al. In vitro percutaneous absorption of thiamine disulfide from a mixture of propylene glycol and fatty acid. J Pharm Sci. 1992 Aug;81(8):744-6.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 886.1±65.0 °C at 760 mmHg
Melting Point 177ºC
Molecular Formula C24H34N8O4S2
Molecular Weight 562.708
Flash Point 489.7±34.3 °C
Exact Mass 562.214417
PSA 235.28000
LogP 2.79
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.669

 Safety Information

RTECS LQ2715000

 Synthetic Route

N,N'-(disulfanediylbis(5-hydroxypent-2-ene-3,2-diyl))bis(N-((4-amino-2-methylpyrimidin-5-yl)methyl)formamide) pentadecanoate structure

N,N'-(disulfane...

CAS#:100502-53-2

~%

Pentadecanoic acid structure

Pentadecanoic acid

CAS#:1002-84-2

Thiamine Disulfide Hydrate Structure

Thiamine Disulf...

CAS#:67-16-3

Literature: Chemical and Pharmaceutical Bulletin, , vol. 38, # 7 p. 1819 - 1823
N,N'-(disulfanediylbis(5-hydroxypent-2-ene-3,2-diyl))bis(N-((4-amino-2-methylpyrimidin-5-yl)methyl)formamide) heptadecanoate structure

N,N'-(disulfane...

CAS#:100502-55-4

~%

Margaric acid structure

Margaric acid

CAS#:506-12-7

Thiamine Disulfide Hydrate Structure

Thiamine Disulf...

CAS#:67-16-3

Literature: Chemical and Pharmaceutical Bulletin, , vol. 38, # 7 p. 1819 - 1823

 Synonyms

Formamide, N,N'-[dithiobis[(Z)-2-(2-hydroxyethyl)-1-methyl-2,1-ethenediyl]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-
MFCD00010427
Thiamine Disulfide
Vitamin B1 Disulfide
EINECS 200-644-4
Aneurine Disulfide
AKTIVIN
N,N'-{Disulfanediylbis[(2Z)-5-hydroxypent-2-ene-3,2-diyl]}bis{N-[(4-amino-2-methylpyrimidin-5-yl)methyl]formamide}
N,N'-{Disulfanediylbis[(2Z)-5-hydroxy-2-pentene-3,2-diyl]}bis{N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamide}
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N-(3,5-dimethoxyphenyl)-2-{7-methyl-3-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]-4-oxo-1,4-dihydro-1,8-naphthyridin-1-yl}acetamide
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N-(2,5-dimethoxybenzyl)-7-(4-ethoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
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N-(2,4-dimethylphenyl)-2-{3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-1-yl}acetamide
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N-(3,5-dimethylphenyl)-2-(3-(3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl)-7-methyl-4-oxo-1,8-naphthyridin-1(4H)-yl)acetamide
1113119-32-6
Chemsrc provides Thiamine Disulfide Hydrate(CAS#:67-16-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Thiamine Disulfide Hydrate are included as well.>> amp version: Thiamine Disulfide Hydrate

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