- DC Chemicals Limited
- China
- Product Name: Thiamine disulfide
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Thiamine disulfide
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Thiamine disulfide
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
67-16-3
67-16-3 structure
- Name: Thiamine Disulfide Hydrate
- Chemical Name: Thiamine Disulfide Hydrate
- CAS Number: 67-16-3
- Molecular Formula: C24H34N8O4S2
- Molecular Weight: 562.708
- Catalog: Biochemical Inhibitor Protein tyrosine kinase
- Create Date: 2018-06-11 12:30:26
- Modify Date: 2024-01-03 07:23:43
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Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity[1][2].
| Name | Thiamine Disulfide Hydrate |
|---|---|
| Synonyms |
Formamide, N,N'-[dithiobis[(Z)-2-(2-hydroxyethyl)-1-methyl-2,1-ethenediyl]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-
MFCD00010427 Thiamine Disulfide Vitamin B1 Disulfide EINECS 200-644-4 Aneurine Disulfide AKTIVIN N,N'-{Disulfanediylbis[(2Z)-5-hydroxypent-2-ene-3,2-diyl]}bis{N-[(4-amino-2-methylpyrimidin-5-yl)methyl]formamide} N,N'-{Disulfanediylbis[(2Z)-5-hydroxy-2-pentene-3,2-diyl]}bis{N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamide} |
| Description | Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Thiamine disulfide markedly inhibits production of progeny HIV-1 in acute and chronic HIV-1-infected CEM at nontoxic concentrations of 500-1000 μM. Thiamine disulfide (500 μM) blocks 99.7% of HIV-1 production after 96 hours culture in acute HIV-1 (LAV-1) infection, whereas it inhibits 90-98% of HIV-1 production in chronic-infected cells (CEM/LAV-1, H9/MN, and Molt-4/IIIB)[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 886.1±65.0 °C at 760 mmHg |
| Melting Point | 177ºC |
| Molecular Formula | C24H34N8O4S2 |
| Molecular Weight | 562.708 |
| Flash Point | 489.7±34.3 °C |
| Exact Mass | 562.214417 |
| PSA | 235.28000 |
| LogP | 2.79 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.669 |
| RTECS | LQ2715000 |
|---|
|
~%
67-16-3 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 38, # 7 p. 1819 - 1823 |
|
~%
67-16-3 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 38, # 7 p. 1819 - 1823 |
| Precursor 2 | |
|---|---|
| DownStream 1 | |
