clofenamide

Modify Date: 2024-01-03 08:52:41

clofenamide Structure
clofenamide structure
Common Name clofenamide
CAS Number 671-95-4 Molecular Weight 270.71
Density 1.699g/cm3 Boiling Point 551.6ºC at 760 mmHg
Molecular Formula C6H7ClN2O4S2 Melting Point 206-207° (Davies); mp 217-219° (Olivier)
MSDS N/A Flash Point 287.4ºC

 Use of clofenamide


Clofenamide (Aquedux) is a carbonic anhydrase (CA) inhibitor. Clofenamide exhibits diuretic activity[1].

 Names

Name 4-chlorobenzene-1,3-disulfonamide
Synonym More Synonyms

 clofenamide Biological Activity

Description Clofenamide (Aquedux) is a carbonic anhydrase (CA) inhibitor. Clofenamide exhibits diuretic activity[1].
Related Catalog
References

[1]. Delbeke FT, et, al. The influence of diuretics on the excretion and metabolism of doping agents. III. Etilamfetamine. Arzneimittelforschung. 1986 Sep;36(9):1413-6.

 Chemical & Physical Properties

Density 1.699g/cm3
Boiling Point 551.6ºC at 760 mmHg
Melting Point 206-207° (Davies); mp 217-219° (Olivier)
Molecular Formula C6H7ClN2O4S2
Molecular Weight 270.71
Flash Point 287.4ºC
Exact Mass 269.95400
PSA 137.08000
LogP 3.19700
Index of Refraction 1.627

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CZ9100000
CHEMICAL NAME :
m-Benzenedisulfonamide, 4-chloro-
CAS REGISTRY NUMBER :
671-95-4
BEILSTEIN REFERENCE NO. :
2142672
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C6-H7-Cl-N2-O4-S2
MOLECULAR WEIGHT :
270.72
WISWESSER LINE NOTATION :
ZSWR BG ESZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
340 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
661 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979

 Safety Information

HS Code 2935009090

 Synthetic Route

~%

clofenamide Structure

clofenamide

CAS#:671-95-4

Literature: Bollettino Chimico Farmaceutico, , vol. 97, p. 451

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Synonyms

Frictan
Eleklin
4-chloro-benzene-1,3-disulfonic acid diamide
Aponiere
Indigatin
4-Chlor-benzol-1,3-disulfonamid
Haflutan
Monochlorphenamide
4-Chlor-benzol-1,3-disulfonsaeure-diamid
Diumide
1-Chlor-2,4-bis-sulfamoyl-benzol
Clofenamide
Mahi
4-chloro-benzene-1,3-disulfonamide
Aquedux
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