Metyrosine
Modify Date: 2024-01-06 22:37:21
Metyrosine structure
|
Common Name | Metyrosine | ||
|---|---|---|---|---|
| CAS Number | 672-87-7 | Molecular Weight | 195.21500 | |
| Density | 1.283g/cm3 | Boiling Point | 383.7ºC at 760 mmHg | |
| Molecular Formula | C10H13NO3 | Melting Point | 320-340°C dec. | |
| MSDS | Chinese USA | Flash Point | 185.9ºC | |
Use of MetyrosineMetyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2]. |
| Name | α-methyl-L-tyrosine |
|---|---|
| Synonym | More Synonyms |
| Description | Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2]. |
|---|---|
| Related Catalog | |
| In Vitro | Metyrosine acts by inhibiting tyrosine hydroxylase, thus causing depletion of adrenal stores of catecholamines[2]. |
| In Vivo | Metyrosine (50-200 mg/kg; i.p.) reduces carrageenan inflammation[1]. Metyrosine (50-200 mg/kg; i.p.) shows antiulcerative activity is 87.7%, 93.7% and 95.5% for 50, 100 and 200 mg/kg doses of metyrosine, respectively[1]. Animal Model: Male albino Wistar rats (carrageenan-induced rat paw edema)[2] Dosage: 50, 100 or 200 mg/kg Administration: I.p. Result: Reduced carrageenan inflammation at 50, 100 and 200 mg/kg doses (40%, 67% and 87%, respectively, at 4 h). |
| References |
| Density | 1.283g/cm3 |
|---|---|
| Boiling Point | 383.7ºC at 760 mmHg |
| Melting Point | 320-340°C dec. |
| Molecular Formula | C10H13NO3 |
| Molecular Weight | 195.21500 |
| Flash Point | 185.9ºC |
| Exact Mass | 195.09000 |
| PSA | 83.55000 |
| LogP | 1.43700 |
| Index of Refraction | 1.599 |
| Storage condition | −20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2922509090 |
| Precursor 3 | |
|---|---|
| DownStream 0 | |
CAS#:121703-96-6
CAS#:2746-25-0
CAS#:122-84-9| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc... |
|
|
FDA-approved drug labeling for the study of drug-induced liver injury.
Drug Discov. Today 16 , 697-703, (2011) Drug-induced liver injury (DILI) is a leading cause of drugs failing during clinical trials and being withdrawn from the market. Comparative analysis of drugs based on their DILI potential is an effec... |
|
|
Effects of intratumoral inflammatory process on 18F-FDG uptake: pathologic and comparative study with 18F-fluoro-α-methyltyrosine PET/CT in oral squamous cell carcinoma.
J. Nucl. Med. 56(1) , 16-21, (2015) The accurate depiction of both biologic and anatomic profiles of tumors has long been a challenge in PET imaging. An inflammation, which is innate in the carcinogenesis of oral squamous cell carcinoma... |
| MFCD00064201 |
| (S)-alpha-Methyltyrosine |
| α-METHYL-L-P-TYROSINE |
| alpha-methyl-L-tyrosine |
| EINECS 211-599-5 |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Metyrosine
- Price: ￥4038.0/500mg ￥708.0/100mg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Racemetirosine
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Nanjing Peptide Biotech Ltd
- China
- Product Name: α-Me-Tyr-OH
- Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
- Purity: 98.0%
- Stocking Period: 7 Day
- Contact: jom
Get all suppliers and price by the below link: