ACTH (4-11)

Modify Date: 2024-01-10 11:57:51

ACTH (4-11) Structure
ACTH (4-11) structure
Common Name ACTH (4-11)
CAS Number 67224-41-3 Molecular Weight 1090.26000
Density 1.46 g/cm3 Boiling Point N/A
Molecular Formula C50H71N15O11S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ACTH (4-11)


ACTH (4-11), an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).

 Names

Name acth (4-11)
Synonym More Synonyms

 ACTH (4-11) Biological Activity

Description ACTH (4-11), an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).
Related Catalog
In Vitro α-melanocyte stimulating hormone (MSH) induces the differentiation of mouse epidermal melanocytes in vivo and in vitro. Adrenocorticotropic hormone (ACTH) possesses the same amino acid sequence as MSH does. α-MSH induces the differentiation of mouse epidermal melanocytes in vivo and in vitro. ACTH (4-11) loses almost all activity for the binding to melanocortin receptor 1 (MC1R)[1].
References

[1]. Hirobe T, et al. ACTH(4-12) is the minimal message sequence required to induce the differentiation of mouse epidermal melanocytes in serum-free primary culture. J Exp Zool. 2000 May 1;286(6):632-40.

 Chemical & Physical Properties

Density 1.46 g/cm3
Molecular Formula C50H71N15O11S
Molecular Weight 1090.26000
Exact Mass 1089.52000
PSA 462.01000
LogP 3.69380
Index of Refraction 1.682
Storage condition 2-8℃

 Synonyms

Methionyl-glutamyl-histidinyl-phenylalanyl-argininyl-tryptophanyl-glycinyl-lysine
MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS
H-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-OH
MEHFRWGK
ADRENOCORTICOTROPIC HORMONE FRAGMENT 4-11
MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS