ACTH (4-10)

Modify Date: 2024-01-02 21:08:58

ACTH (4-10) Structure
ACTH (4-10) structure
Common Name ACTH (4-10)
CAS Number 4037-01-8 Molecular Weight 962.09
Density 1.48g/cm3 Boiling Point N/A
Molecular Formula C44H59N13O10S Melting Point N/A
MSDS USA Flash Point N/A

 Use of ACTH (4-10)


Adrenocorticotropic Hormone (ACTH) (4-10), human is a melanocortin 4 (MC4R) receptor agonist.

 Names

Name met-glu-his-phe-arg-trp-gly
Synonym More Synonyms

 ACTH (4-10) Biological Activity

Description Adrenocorticotropic Hormone (ACTH) (4-10), human is a melanocortin 4 (MC4R) receptor agonist.
Related Catalog
Target

Melanocortin 4 receptor[1]

In Vitro Adrenocorticotropic Hormone (ACTH) (4-10), human (ACTH (4-10)) is the core sequence of all melanocortins and binds selectively to MC4-R. In humans, ACTH (4-10) enters the cerebral fluid compartment after intranasal application and leads to a decrease in total body fat after 6 weeks of continuous treatment[1].
References

[1]. Wellhöner P, et al. Intranasal application of the melanocortin 4 receptor agonist MSH/ACTH(4-10) in humans causes lipolysis in white adipose tissue. Int J Obes (Lond). 2012 May;36(5):703-8.

 Chemical & Physical Properties

Density 1.48g/cm3
Molecular Formula C44H59N13O10S
Molecular Weight 962.09
PSA 183.70000
LogP 9.43540
Vapour Pressure 4.64E-09mmHg at 25°C
Index of Refraction 1.547

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles30

More Articles
Ligand-dependent activation of the melanocortin 5 receptor: cAMP production and ryanodine receptor-dependent elevations of [Ca(2+)](I).

Biochem. Biophys. Res. Commun. 290 , 844-850, (2002)

The melanocortins are involved in the regulation of various cognitive and physiological processes such as learning, feeding, immune suppression, pigmentation, and sebum production. Five melanocortin r...

Sniffing neuropeptides: a transnasal approach to the human brain.

Nat. Neurosci. 5(6) , 514-6, (2002)

The melanocortin melanocyte-stimulating hormone/adrenocorticotropin(4-10) decreases body fat in humans.

J. Clin. Endocrinol. Metab. 86(3) , 1144-8, (2001)

The control of body fat is a prominent factor in human health. Animal studies have indicated a homeostatic central nervous system regulation of body fat with particular involvement of the melanocortin...

 Synonyms

Adrenalonium chloratum
adrenalon hydrochloride
Adrenone hydrochloride
ADRENALONE,HYDROCHLORIDE
Stryphnonasal
Kephrine hydrochloride
Epinephrine ketone hydrochloride
ADRENALONE HCL
Adrenocorticotropic Hormone (ACTH) (4-10), human