GBR 12783 dihydrochloride
Modify Date: 2024-04-03 19:10:03
GBR 12783 dihydrochloride structure
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Common Name | GBR 12783 dihydrochloride | ||
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| CAS Number | 67469-57-2 | Molecular Weight | 485.488 | |
| Density | 1.085 g/cm3 | Boiling Point | 550.5ºC at 760 mmHg | |
| Molecular Formula | C28H32N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 148.1ºC | |
Use of GBR 12783 dihydrochlorideGBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 can improve memory performance and increase hippocampal acetylcholine release in rats[1][2]. |
| Name | 1-(2-benzhydryloxyethyl)-4-(3-phenylprop-2-enyl)piperazine,dihydrochloride |
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| Synonym | More Synonyms |
| Description | GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 can improve memory performance and increase hippocampal acetylcholine release in rats[1][2]. |
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| Related Catalog | |
| In Vivo | GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task[1]. Animal Model: Male Sprague-Dawley rats (180-200 g)[1] Dosage: 10 mg/kg Administration: Intraperitoneal injection; for 100 minutes Result: For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo. |
| References |
| Density | 1.085 g/cm3 |
|---|---|
| Boiling Point | 550.5ºC at 760 mmHg |
| Molecular Formula | C28H32N2O |
| Molecular Weight | 485.488 |
| Flash Point | 148.1ºC |
| Exact Mass | 484.204834 |
| PSA | 15.71000 |
| LogP | 6.60340 |
| Index of Refraction | 1.601 |
| Storage condition | -20°C |
| HS Code | 2933599090 |
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| HS Code | 2933599090 |
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| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 1-[2-(Diphenylmethoxy)ethyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine dihydrochloride |
| 1-[2-(Diphenylmethoxy)ethyl]-4-[(2E)-3-phenyl-2-propen-1-yl]piperazine dihydrochloride |
| Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-, hydrochloride (1:2) |