GBR 12783 dihydrochloride
Modify Date: 2024-01-30 11:51:01
GBR 12783 dihydrochloride structure
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Common Name | GBR 12783 dihydrochloride | ||
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| CAS Number | 67469-75-4 | Molecular Weight | 485.48800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H34Cl2N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GBR 12783 dihydrochlorideGBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats[1][2]. |
| Name | 1-[2-(Diphenylmethoxy)ethyl]-4-[(2E)-3-phenyl-2-propen-1-yl]piper azine dihydrochloride |
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| Synonym | More Synonyms |
| Description | GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats[1][2]. |
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| Related Catalog | |
| In Vivo | GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task[1]. Animal Model: Male Sprague-Dawley rats (180-200 g)[1] Dosage: 10 mg/kg Administration: Intraperitoneal injection; for 100 minutes Result: For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo. |
| References |
| Molecular Formula | C28H34Cl2N2O |
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| Molecular Weight | 485.48800 |
| Exact Mass | 484.20500 |
| PSA | 15.71000 |
| LogP | 6.60340 |
| Hazard Codes | Xi |
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~49%
GBR 12783 dihyd... CAS#:67469-75-4 |
| Literature: Van Der Zee; Koger; Gootjes; Hespe European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 363 - 370 |
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