N-[(2S,3R)-3-氨基-2-羟基-5-甲基-1-氧代己基]-L-缬氨酰-L-缬氨酰-L-天冬氨酸

• 常用名: N-[(2S,3R)-3-氨基-2-羟基-5-甲基-1-氧代己基]-L-缬氨酰-L-缬氨酰-L-天冬氨酸
• 英文名: AMASTATIN
• CAS号: 67655-94-1
• 分子量: 474.54800
• 密度: 1.228g/cm3
• 沸点: 795.1ºC at 760 mmHg
• 分子式: C₂₁H₃₈N₄O₈
• 熔点: N/A
• 闪点: 434.7ºC

用途

Amastatin is a non-toxic inhibitor of aminopeptidase A (Ki = 1 μM) and leucine aminopeptidase. Also acts as a slow-binding, competitive inhibitor of aminopeptidase M. Does not inhibit aminopeptidase B, chymotrypsin, elastase, papain, pepsin, thermolysin, or trypsin.

名称

• 中文名: N-[(2S,3R)-3-氨基-2-羟基-5-甲基-1-氧代己基]-L-缬氨酰-L-缬氨酰-L-天冬氨酸
• 英文名: amastatin

物理化学性质

• 密度: 1.228g/cm3
• 沸点: 795.1ºC at 760 mmHg
• 分子式: C₂₁H₃₈N₄O₈
• 分子量: 474.54800
• 闪点: 434.7ºC
• 精确质量: 474.26900
• PSA: 208.15000
• LogP: 0.91940
• InChIKey: QFAADIRHLBXJJS-ZAZJUGBXSA-N
• SMILES: CC(C)CC(N)C(O)C(=O)NC(C(=O)NC(C(=O)NC(CC(=O)O)C(=O)O)C(C)C)C(C)C
• 折射率: 1.523

毒性和生态

安全信息

• 危害码 (欧洲): Xi

靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-KMS_34-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_L363-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OCIMY7-m4-1

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英文别名

• amastatin,streptomyces species