Gigantol
Modify Date: 2024-01-08 19:14:21
Gigantol structure
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Common Name | Gigantol | ||
|---|---|---|---|---|
| CAS Number | 67884-30-4 | Molecular Weight | 274.31200 | |
| Density | 1.204±0.06 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C16H18O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GigantolGigantol is a bibenzyl compound derived from several medicinal orchids. Giganto shows promising therapeutic potential against cancer cells. Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. |
| Name | 5-[2-(3-hydroxy-5-methoxyphenyl)ethyl]-2-methoxyphenol |
|---|---|
| Synonym | More Synonyms |
| Description | Gigantol is a bibenzyl compound derived from several medicinal orchids. Giganto shows promising therapeutic potential against cancer cells. Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. |
|---|---|
| Related Catalog | |
| Target |
Wnt[1] |
| In Vitro | Gigantol decreases the level of phosphorylated LRP6 and cytosolic β-catenin in HEK293 cells. In breast cancer MDA-MB-231 and MDA-MB-468 cells, treatment with gigantol reduces the level of phosphorylated LRP6[1]. Gigantol significantly inhibits the proliferation and induces apoptosis of the HepG2 cells. Gigantol at concentrations of 1, 40 and 150 µM markedly decreases the cell viability by 11.7, 30.0 and 56.4% at 24 h and 21.1, 66.8 and 85.5% at 48 h, respectively. The IC50 value is 9.30 µM[2]. |
| In Vivo | LDD and gigantol (25–100 mg/kg, p.o.) significantly increase the hot-plate latency in comparison to vehicle-treated mice and decreased carrageenaninduced inflammation in rats[2]. |
| Cell Assay | HepG2 cells are treated with a series of concentrations of Gigantol (1, 10, 40, 80 and 150 µM) for different time intervals (12, 24 and 48 h). The cytotoxicity is measured using MTT assays[2]. |
| Animal Admin | Rats[3] The anti-inflammatory activity is determined by carrageenan-induced edema test in the hind paws of rats. Sprague-Dawley rats are fasted for 15 h before the experiment with free access to water. One hundred microlitres of 1% carrageenan (10 mg/mL, Type IV, lambda) suspension is prepared 30 min before each experiment and injected into the plantar side of right hindpaw of the rats. The CH2Cl2-MeOH Scaphyglottis livida and Maxillaria densa extracts (150-600 mg/kg), as well as compound LDD and gigantol (25-100 mg/kg), are orally administered. The extracts, LDD and gigantol are administered 1 h before the carrageenan treatment[3]. Mice[3] Mice receive an oral administration of vehicle (0.2% Tween-80) or increasing doses of Scaphyglottis livida and Maxillaria densa extracts (150–600 mg/kg) or LDD and gigantol (25-100 mg/kg) 30 min before the thermal noxious stimuli in the hot-plate test. Morphine (1.5-6 mg/kg, p.o.) is used as positive control. Mice are observed before and at 30, 60, 90 and 120 min after drugs administration[3]. |
| References |
| Density | 1.204±0.06 g/cm3 |
|---|---|
| Molecular Formula | C16H18O4 |
| Molecular Weight | 274.31200 |
| Exact Mass | 274.12100 |
| PSA | 58.92000 |
| LogP | 2.90020 |
| Water Solubility | Very slightly soluble (0.15 g/L) (25 ºC) |
| Hazard Codes | Xi |
|---|
| Gigantol |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Gigantol
- Price: Click To Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Gigantol
- Price: ￥Inquiry/1mg
- Purity: 98.0%
- Delivery: 1 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Dendrophenol
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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Price: ￥2420/10 mM * 1 mL in DMSO
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