Tetrahydro-11-deoxy Cortisol

Modify Date: 2024-01-16 11:17:42

Tetrahydro-11-deoxy Cortisol Structure
Tetrahydro-11-deoxy Cortisol structure
Common Name Tetrahydro-11-deoxy Cortisol
CAS Number 68-60-0 Molecular Weight 350.49200
Density 1.186g/cm3 Boiling Point 505.1ºC at 760 mmHg
Molecular Formula C21H34O4 Melting Point N/A
MSDS Chinese USA Flash Point 273.4ºC

 Use of Tetrahydro-11-deoxy Cortisol


Tetrahydro-11-deoxycortisol (Tetrahydrodeoxycortisol) is an endogenous metabolite present in Urine that can be used for the research of 11 Beta Hydroxylase Deficiency[1][2].

 Names

Name 1-[(3R,5R,8R,9S,10S,13S,14S,17R)-3,17-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2-hydroxyethanone
Synonym More Synonyms

 Tetrahydro-11-deoxy Cortisol Biological Activity

Description Tetrahydro-11-deoxycortisol (Tetrahydrodeoxycortisol) is an endogenous metabolite present in Urine that can be used for the research of 11 Beta Hydroxylase Deficiency[1][2].
Related Catalog
In Vitro Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].
References

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.  

[2]. Burren CP, et al. CYP11 beta 1 (11-beta-hydroxylase) deficiency in congenital adrenal hyperplasia. J Paediatr Child Health. 1996 Oct;32(5):433-8.  

 Chemical & Physical Properties

Density 1.186g/cm3
Boiling Point 505.1ºC at 760 mmHg
Molecular Formula C21H34O4
Molecular Weight 350.49200
Flash Point 273.4ºC
Exact Mass 350.24600
PSA 77.76000
LogP 2.68250
Index of Refraction 1.56

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Precursor & DownStream

Precursor  0

DownStream  2

 Articles26

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[Urinary tetrahydro-11-deoxycortisol].

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A quantitative in vivo mouse model used to assay inhibitors of tumor-induced angiogenesis.

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 Synonyms

tetrahydrocortexolone
5beta-Pregnane-3alpha,17alpha,21-triol-20-one
3alpha,17alpha,21-Trihydroxy-5beta-pregnan-20-one
EINECS 200-691-0
Tetrahydrodeoxycortisol
Tetrahydro-11-deoxycortisol