PIN1 inhibitor API-1

Modify Date: 2025-08-25 09:13:58

PIN1 inhibitor API-1 structure	Common Name	PIN1 inhibitor API-1
	CAS Number	680622-70-2	Molecular Weight	366.29800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₅F₃N₆O₂	Melting Point	208-211C
	MSDS	N/A	Flash Point	N/A

Use of PIN1 inhibitor API-1

PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development[1].

Name	O6-[4-(Trifluoroacetamidomethyl)benzyl]guanine
Synonym	More Synonyms

Description	PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 72.3 nM (Pin1)[1]
In Vitro	PIN1 inhibitor API-1 obviously inhibits SK-Hep-1, SNU-423, and Hep3B cell proliferation with low IC50 values (IC50=0.683-4.16 μM)[1].
In Vivo	PIN1 inhibitor API-1 suppresses tumor growth in mice by up-regulating mature miRNA biogenesis[1].
References	[1]. Pu W, et al. Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellularcarcinoma development. Hepatology. 2018 Aug;68(2):547-560.

Melting Point	208-211C
Molecular Formula	C₁₅H₁₅F₃N₆O₂
Molecular Weight	366.29800
Exact Mass	366.10500
PSA	123.03000
LogP	2.46300

Precursor 0
DownStream 1
CAS#:674799-96-3 6-((4-(Aminomet...

N-[[4-[(2-amino-7H-purin-6-yl)oxymethyl]phenyl]methyl]-2,2,2-trifluoroacetamide

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China
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: O6-[4-(TRIFLUOROACETAMIDOMETHYL)BENZYL]GUANINE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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PIN1 inhibitor API-1

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