Elasnin

Modify Date: 2024-01-19 11:08:07

Elasnin Structure
Elasnin structure
 Common Name Elasnin
CAS Number 68112-21-0 Molecular Weight 392.57
Density 1.001g/cm3 Boiling Point 521ºC at 760 mmHg
Molecular Formula C24H40O4 Melting Point N/A
MSDS N/A Flash Point 166.6ºC

 Use of Elasnin


Elasnin is a selective granulocyte elastase inhibitor. Elasnin is almost ineffective for pancreatic elastase, trypsin, chymotrypsin, thermolysin and papain[1].

 Names

Name 3,5-dibutyl-4-hydroxy-6-(6-oxoundecan-5-yl)pyran-2-one
Synonym More Synonyms

 Elasnin Biological Activity

Description Elasnin is a selective granulocyte elastase inhibitor. Elasnin is almost ineffective for pancreatic elastase, trypsin, chymotrypsin, thermolysin and papain[1].
Related Catalog
References

[1]. S Omura, et al. Elasnin, a new human granulocyte elastase inhibitor produced by a strain of Streptomyces. Biochem Biophys Res Commun. 1978 Jul 28;83(2):704-9.  

 Chemical & Physical Properties

Density 1.001g/cm3
Boiling Point 521ºC at 760 mmHg
Molecular Formula C24H40O4
Molecular Weight 392.57
Flash Point 166.6ºC
Exact Mass 392.29300
PSA 67.51000
LogP 6.45380
Index of Refraction 1.491

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ0509600
CHEMICAL NAME :
2H-Pyran-2-one, 3,5-dibutyl-6-(1-butyl-2-oxoheptyl)-4-hydroxy-
CAS REGISTRY NUMBER :
68112-21-0
BEILSTEIN REFERENCE NO. :
1265379
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C24-H40-O4
MOLECULAR WEIGHT :
392.64

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 31,1116,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
290 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 31,1116,1978

 Synthetic Route

N/A structure

N/A

CAS#:73907-88-7

~66%

Elasnin Structure

Elasnin

CAS#:68112-21-0

Literature: Shone; Deason; Miyano Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270
O-acetylelasnin structure

O-acetylelasnin

CAS#:73891-54-0

~92%

Elasnin Structure

Elasnin

CAS#:68112-21-0

Literature: Pfister, Juerg R. Tetrahedron Letters, 1980 , vol. 21, p. 1281 - 1284
(E)-3,5-dibutyl-2-oxo-6-(undec-5-en-5-yl)-2H-pyran-4-yl acetate structure

(E)-3,5-dibutyl...

CAS#:74583-81-6

~%

Elasnin Structure

Elasnin

CAS#:68112-21-0

Literature: Pfister, Juerg R. Tetrahedron Letters, 1980 , vol. 21, p. 1281 - 1284
3,5-dibutyl-6-(2-butyl-3-pentyloxiran-2-yl)-2-oxo-2H-pyran-4-yl acetate structure

3,5-dibutyl-6-(...

CAS#:74583-82-7

~%

Elasnin Structure

Elasnin

CAS#:68112-21-0

Literature: Pfister, Juerg R. Tetrahedron Letters, 1980 , vol. 21, p. 1281 - 1284
1-imidazol-1-ylhexan-1-one structure

1-imidazol-1-yl...

CAS#:60988-34-3

~%

Elasnin Structure

Elasnin

CAS#:68112-21-0

Literature: Shone; Deason; Miyano Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270
methyl 2-butyl-3-oxooctanoate structure

methyl 2-butyl-...

CAS#:74583-78-1

~%

Elasnin Structure

Elasnin

CAS#:68112-21-0

Literature: Shone; Deason; Miyano Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270
3,5-dibutyl-4-hydroxy-6-pentylpyran-2-one structure

3,5-dibutyl-4-h...

CAS#:65837-08-3

~%

Elasnin Structure

Elasnin

CAS#:68112-21-0

Literature: Shone; Deason; Miyano Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270
methyl 2,4-dibutyl-3,5-dioxodecanoate structure

methyl 2,4-dibu...

CAS#:99903-27-2

~%

Elasnin Structure

Elasnin

CAS#:68112-21-0

Literature: Shone; Deason; Miyano Journal of Organic Chemistry, 1986 , vol. 51, # 2 p. 268 - 270
3,5-dibutyl-6-(6-hydroxyundecan-5-yl)-2-oxo-2H-pyran-4-yl acetate structure

3,5-dibutyl-6-(...

CAS#:74583-83-8

~%

Elasnin Structure

Elasnin

CAS#:68112-21-0

Literature: Pfister, Juerg R. Tetrahedron Letters, 1980 , vol. 21, p. 1281 - 1284

 Synonyms

Elasnin
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