Isoliensinine

Modify Date: 2024-01-05 11:00:53

Isoliensinine Structure
Isoliensinine structure
Common Name Isoliensinine
CAS Number 6817-41-0 Molecular Weight 610.739
Density 1.2±0.1 g/cm3 Boiling Point 723.1±60.0 °C at 760 mmHg
Molecular Formula C37H42N2O6 Melting Point 69-71℃
MSDS N/A Flash Point 391.1±32.9 °C

 Use of Isoliensinine


Isoliensinine is a bisbenzylisoquinoline alkaloid extracted from the seed embryo of Nelumbo nucifera, with anti-oxidant and anti-inflammatory and anti-cancer activities. Isoliensinine induces apoptosis in triple-negative human breast cancer cells[1][2].

 Names

Name (1R)-1-[[4-hydroxy-3-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenyl]methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
Synonym More Synonyms

 Isoliensinine Biological Activity

Description Isoliensinine is a bisbenzylisoquinoline alkaloid extracted from the seed embryo of Nelumbo nucifera, with anti-oxidant and anti-inflammatory and anti-cancer activities. Isoliensinine induces apoptosis in triple-negative human breast cancer cells[1][2].
Related Catalog
In Vitro Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation[1]. Isoliensinine exerts antiproliferative effect on CASMCs induced by phenylephrine, and its mechanisms are related to decrease the overexpression of growth factors (PDGF-beta, bFGF), protooncogene (c-fos, c-myc) and hsp70[3].
References

[1]. Zhang X, et al. Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation. Sci Rep. 2015 Jul 29;5:12579.

[2]. Xiao JH, et al. Effects of isoliensinine on proliferation of porcine coronary arterial smooth muscle cells induced by phenylephrine. Yao Xue Xue Bao. 2005 Feb;40(2):105-10.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 723.1±60.0 °C at 760 mmHg
Melting Point 69-71℃
Molecular Formula C37H42N2O6
Molecular Weight 610.739
Flash Point 391.1±32.9 °C
Exact Mass 610.304260
PSA 83.86000
LogP 4.72
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.618
Storage condition 2-8°C

 Safety Information

Hazard Codes Xn

 Synonyms

(1R)-1-(4-Hydroxy-3-{[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydro-7-isoquinolinyl]oxy}benzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydro-7-isoquinolinol
Isoliensinin
(1R)-1-(4-Hydroxy-3-{[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol
7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[[4-hydroxy-3-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]phenyl]methyl]-6-methoxy-2-methyl-, (1R)-
Isoliensinine
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