IWP-3

Modify Date: 2024-01-04 15:25:25

IWP-3 Structure
IWP-3 structure
 Common Name IWP-3
CAS Number 687561-60-0 Molecular Weight 484.589
Density 1.6±0.1 g/cm3 Boiling Point N/A
Molecular Formula C22H17FN4O2S3 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07		 Signal Word Warning

 Use of IWP-3


IWP-3 is an potent inhibitor of Wnt production with an IC50 of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 inhibits CK1γ3 and CK1ε only moderately and does not inhibit CK1α[1][2].

 Names

Name 2-{[3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrim idin-2-yl]sulfanyl}-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide
Synonym More Synonyms

 IWP-3 Biological Activity

Description IWP-3 is an potent inhibitor of Wnt production with an IC50 of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 inhibits CK1γ3 and CK1ε only moderately and does not inhibit CK1α[1][2].
Related Catalog
Target

Wnt:40 nM (IC50)

References

[1]. Baozhi Chen, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009 Feb;5(2):100-7.

[2]. Balbina García-Reyes, et al. Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. J Med Chem. 2018 May 10;61(9):4087-4102.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Molecular Formula C22H17FN4O2S3
Molecular Weight 484.589
Exact Mass 484.049774
PSA 159.21000
LogP 5.30
Index of Refraction 1.776

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
RIDADR NONH for all modes of transport

 Synonyms

Acetamide, 2-[[3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-N-(6-methyl-2-benzothiazolyl)-
2-{[3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl}-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide
IWP-3
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Chemsrc provides IWP-3(CAS#:687561-60-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of IWP-3 are included as well.>> amp version: IWP-3

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