(±)-Hexanoylcarnitine chloride

Modify Date: 2024-01-15 22:33:01

(±)-Hexanoylcarnitine chloride Structure
(±)-Hexanoylcarnitine chloride structure
Common Name (±)-Hexanoylcarnitine chloride
CAS Number 6920-35-0 Molecular Weight 295.80
Density N/A Boiling Point N/A
Molecular Formula C13H26ClNO4 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of (±)-Hexanoylcarnitine chloride


(±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into energy that can be used by the body. (±)-Hexanoylcarnitine chloride also serves as a specific and easily detectable biomarker for rat skeletal muscle toxicity. Cerivastatin (HY-129458) and TMPD (HY-W012145) induce an increase in Hexanoylcarnitine in rats in a metabolomic analysis of the rectus femoris muscle. In type 2 diabetes, Hexanoylcarnitine is also significantly associated with and improves prediction of all-cause mortality. Hexanoylcarnitine is a biomarker for the identification of novel pathogenic pathways[1][2].

 Names

Name (3-carboxy-2-hexanoyloxypropyl)-trimethylazanium,hydrochloride
Synonym More Synonyms

 (±)-Hexanoylcarnitine chloride Biological Activity

Description (±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into energy that can be used by the body. (±)-Hexanoylcarnitine chloride also serves as a specific and easily detectable biomarker for rat skeletal muscle toxicity. Cerivastatin (HY-129458) and TMPD (HY-W012145) induce an increase in Hexanoylcarnitine in rats in a metabolomic analysis of the rectus femoris muscle. In type 2 diabetes, Hexanoylcarnitine is also significantly associated with and improves prediction of all-cause mortality. Hexanoylcarnitine is a biomarker for the identification of novel pathogenic pathways[1][2].
Related Catalog
References

[1]. Scarale MG, et al. Circulating Metabolites Associate With and Improve the Prediction of All-Cause Mortality in Type 2 Diabetes. Diabetes. 2022 Jun 1;71(6):1363-1370.  

[2]. Obayashi H, et al. Plasma 2-hydroxyglutarate and hexanoylcarnitine levels are potential biomarkers for skeletal muscle toxicity in male Fischer 344 rats. J Toxicol Sci. 2017;42(4):385-396.  

 Chemical & Physical Properties

Molecular Formula C13H26ClNO4
Molecular Weight 295.80
Exact Mass 295.15500
PSA 63.60000

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H317
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn
Risk Phrases 22-43
Safety Phrases 36/37
RIDADR NONH for all modes of transport
HS Code 2923900090

 Customs

HS Code 2923900090
Summary 2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Articles10

More Articles
Production of acyl-carnitines from the metabolism of [U-14C]3-methyl-2-oxopentanoate by rat liver and skeletal muscle mitochondria.

Clin. Invest. Med. 18(2) , 144-51, (1995)

A sensitive method of continuous on-line radio-high performance liquid chromatography (HPLC) was used to detect the specific radio-labelled acyl-carnitine esters derived from the oxidation of [U-14C]3...

Analysis of mitochondrial fatty acid oxidation intermediates by tandem mass spectrometry from intact mitochondria prepared from homogenates of cultured fibroblasts, skeletal muscle cells, and fresh muscle.

Pediatr. Res. 52(1) , 64-70, (2002)

Defects of mitochondrial fatty acid beta-oxidation are an important group of inherited metabolic disorders in children. Despite improved screening opportunities, diagnosis of these disorders is not of...

Metabolomics identifies perturbations in human disorders of propionate metabolism.

Clin. Chem. 53(12) , 2169-76, (2007)

We applied untargeted mass spectrometry-based metabolomics to the diseases methylmalonic acidemia (MMA) and propionic acidemia (PA).We used a screening platform that used untargeted, mass-based metabo...

 Synonyms

Ruthenium Red
DL-Hexanoylcarnitine chloride
DL-Caproylcarnitine chloride
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