Harpagide

Modify Date: 2024-01-02 08:29:57

Harpagide Structure
Harpagide structure
 Common Name Harpagide
CAS Number 6926-08-5 Molecular Weight 364.345
Density 1.7±0.1 g/cm3 Boiling Point 637.1±55.0 °C at 760 mmHg
Molecular Formula C15H24O10 Melting Point N/A
MSDS N/A Flash Point 339.1±31.5 °C

 Use of Harpagide


Harpagide is a class of iridoid glycoside isolated from Scrophularia cryptophila and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.b. rhodesiense) with an IC50 of 21 μg/mL. Harpagide exerts significant antileishmanial activity against L. donovani with an IC50 value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities[1][2].

 Names

Name Harpagide
Synonym More Synonyms

 Harpagide Biological Activity

Description Harpagide is a class of iridoid glycoside isolated from Scrophularia cryptophila and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.b. rhodesiense) with an IC50 of 21 μg/mL. Harpagide exerts significant antileishmanial activity against L. donovani with an IC50 value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities[1][2].
Related Catalog
In Vitro Harpagide shows cytotoxic activity over 50% in a concentration of 90 μg/mL, Harpagide on the A431 and HeLa cell lines. The cytotoxic effect of Harpagide on the MCF7 cell line in a concentration of 90 μg/mL[3].
References

[1]. Tasdemir D, et al. Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of Scrophularia cryptophila. Phytomedicine. 2008 Mar;15(3):209-15.

[2]. Zhang L, et al. Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. Bioorg Med Chem. 2011 Aug 15;19(16):4882-6.

[3]. Háznagy-Radnai E, et al. Cytotoxic activities of Stachys species. Fitoterapia. 2008 Dec;79(7-8):595-7.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 637.1±55.0 °C at 760 mmHg
Molecular Formula C15H24O10
Molecular Weight 364.345
Flash Point 339.1±31.5 °C
Exact Mass 364.136932
PSA 169.30000
LogP -3.69
Vapour Pressure 0.0±4.3 mmHg at 25°C
Index of Refraction 1.663

 Safety Information

Safety Phrases 24/25

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

4a,5,7-Trihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-1-yl hexopyranoside
einecs 230-050-0
Hexopyranoside, 1,4a,5,6,7,7a-hexahydro-4a,5,7-trihydroxy-7-methylcyclopenta[c]pyran-1-yl
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Chemsrc provides Harpagide(CAS#:6926-08-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Harpagide are included as well.>> amp version: Harpagide

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