Thymopentin

Modify Date: 2026-06-30 07:15:30

Thymopentin Structure
Thymopentin structure
Common Name Thymopentin
CAS Number 69558-55-0 Molecular Weight 679.765
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C30H49N9O9 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of Thymopentin


Thymopentin is a biologically active peptide secreted mainly by the epithelial cells of thymic cortex and medulla. Thymopentin is an effective immunomodulatory agent with a short plasma half-life of 30 seconds. Thymopentin enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs)[1][2].

 Names

Name Thymopentin
Synonym More Synonyms

 Thymopentin Biological Activity

Description Thymopentin is a biologically active peptide secreted mainly by the epithelial cells of thymic cortex and medulla. Thymopentin is an effective immunomodulatory agent with a short plasma half-life of 30 seconds. Thymopentin enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs)[1][2].
Related Catalog
In Vitro Thymopentin enhances the generation of T-cell lineage derived from hESCs in vitro [1].
References

[1]. Zhu MX, et al. Thymopentin enhances the generation of T-cell lineage derived from human embryonic stem cells in vitro. Exp Cell Res. 2015 Feb 15;331(2):387-98.

[2]. Lin S, et al. Novel strategy for immunomodulation: Dissolving microneedle array encapsulating thymopentin fabricated by modified two-step molding technology. Eur J Pharm Biopharm. 2018 Jan;122:104-112.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C30H49N9O9
Molecular Weight 679.765
Exact Mass 679.365295
PSA 325.17000
LogP -0.89
Index of Refraction 1.636
InChIKey PSWFFKRAVBDQEG-YGQNSOCVSA-N
SMILES CC(C)C(NC(=O)C(CC(=O)O)NC(=O)C(CCCCN)NC(=O)C(N)CCCN=C(N)N)C(=O)NC(Cc1ccc(O)cc1)C(=O)O
Storage condition −20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3

 Synthetic Route

 Articles41

More Articles
Stability and aerosolization of pressurized metered dose inhalers containing thymopentin nanoparticles produced using a bottom-up process.

Int. J. Pharm. 427(2) , 385-92, (2012)

The objective of this study was to investigate the stability and aerosolization of pressurized metered dose inhalers (pMDIs) containing thymopentin nanoparticles. Thymopentin nanoparticles, fabricated...

Separation and purification of thymopentin with molecular imprinting membrane by solid phase extraction disks.

J. Pharm. Biomed. Anal. 102 , 137-43, (2014)

The synthesis and performance of molecularly imprinted membranes (MIMs) as a solid phase extraction packing materials for the separation and purification of thymopentin from crude samples was describe...

[Vulvar lesions caused by Papillomavirus (HPV): effectiveness of thymopentin (Syntomoduline). First results and experiences].

Minerva Ginecol. 43(1-2) , 53-6, (1991)

The study included two different sized groups of patients suffering from various degrees of valvular microcondylomatosis. A group of 40 patients was treated using combined therapy while a second group...

 ThymopentinBioassay

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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
Name: Compound was evaluated for inhibition of rat Gabra1 in an in vitro assay with cellula...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291801
Name: Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291798
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
Name: Binding affinity towards human ESR1 in an in vitro cell free assay (NIBR assay) measu...
Source: ChEMBL
Target: Estrogen receptor
External Id: CHEMBL5291791
Name: High throughput fluorescence intensity-based biochemical assay to screen for small mo...
Source: University of Pittsburgh Molecular Library Screening Center
Target: furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens]
External Id: MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.
Name: Binding efficacy expressed as counts remaining after competition was subtracted from ...
Source: ChEMBL
Target: CCRF-CEM
External Id: CHEMBL653907
Name: Ability to bound CEM cell measured as competition for displacement of radiolabeled Th...
Source: ChEMBL
Target: CCRF-CEM
External Id: CHEMBL660064
Name: Identifying Sarm1 Tir Hydrolase inhibitors through NAD-Glo assay
Source: 24386
Target: N/A
External Id: Sarm1 Tir NADase inhibitors screen
Name: Binding affinity towards human EDNRA in an in vitro assay with cellular components me...
Source: ChEMBL
Target: Endothelin-1 receptor
External Id: CHEMBL5291785
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 Synonyms

TP-5
RKDVY
THYMOPENTIN 5
Thymopentin
Arg-Lys-Asp-Val-Tyr
thymopoietin
MFCD00214200
N-[N-[N-(N2-L-Arginyl-L-lysyl)-L-a-aspartyl]-L-valyl]-L-tyrosine
THYMOPETIN
L-Arginyl-L-lysyl-L-α-aspartyl-L-valyl-L-tyrosine
thymopoietin fragment 32-36
Timunox
HArgLysAspValTyrOH
Immunox
N-(diaminomethylidene)-L-ornithyl-L-lysyl-L-α-aspartyl-L-valyl-L-tyrosine
Thymopoietin 32-36
THYMOPOIETIN PENTAPEPTIDE
Sintomodulina
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