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700-49-2

700-49-2 structure
700-49-2 structure
  • Name: TCMDC-124283
  • Chemical Name: 2-fluoroadenine
  • CAS Number: 700-49-2
  • Molecular Formula: C5H4FN5
  • Molecular Weight: 153.12
  • Catalog: Biochemical Nucleoside drugs Nucleotides and their analogues
  • Create Date: 2018-06-13 22:54:14
  • Modify Date: 2025-08-25 13:39:34
  • 2-Fluoroadenine is a toxic purine bases. 2-Fluoroadenine has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for researching anticancer[1].
Name 2-fluoroadenine
Synonyms 2-fluoro-adenin
2-FLUORO-6-AMINOPURINE
7H-Purin-6-amine, 2-fluoro-
2-fluoro-9H-purin-6-amine
2-Fluoroadenine
6-AMINO-2-FLUOROPURINE
TCMDC-124283
MFCD01632749
2-fluoropurine
2-fluoroadenibe
2-Fluoro-1H-purin-6-amine
2-fad
6-amino-2-fluoro-purin
BUTTPARK 25 1-01
2-fluoradenine
2-fluoro-1h-purin-6-amin
Description 2-Fluoroadenine is a toxic purine bases. 2-Fluoroadenine has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for researching anticancer[1].
Related Catalog
Target

DNA/RNA synthesis[1]

In Vitro 2-Fluoroadenine (2 μM; 4 hours) inhibits CEM cell growth by targeting one or more enzymes involved in either RNA or protein synthesis[1]. 2-Fluoroadenine (0-1000 μM; 96 hours) exhibits cytotoxicity in nonproliferating MRC-5 cells[1]. 2-Fluoroadenine (0.22, 2.2 and 22 μM; 30 hours) inhibits protein, RNA, and DNA syntheses in Balb-3T3 cells incubated in serum-free medium[1]. Cell Proliferation Assay Cell Line: CEM cells[1] Concentration: 2 μM Incubation Time: 4 hours Result: Inhibited CEM cell growth by targeting one or more enzymes involved in either RNA or protein synthesis. Cell Cytotoxicity Assay Cell Line: MRC-5 cells[1] Concentration: 0-1000 μM Incubation Time: 4 hours Result: Exhibited cytotoxicity in nonproliferating MRC-5 cells.
References

[1]. Parker WB, et al. Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells. Biochem Pharmacol. 1998;55(10):1673-1681.
Density 1.7±0.1 g/cm3
Boiling Point 676.9±58.0 °C at 760 mmHg
Melting Point >350 °C(lit.)
Molecular Formula C5H4FN5
Molecular Weight 153.12
Flash Point 363.2±32.3 °C
Exact Mass 153.045074
PSA 80.48000
LogP -0.01
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.783
Storage condition Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU6264700
CHEMICAL NAME :
Adenine, 2-fluoro-
CAS REGISTRY NUMBER :
700-49-2
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C5-H4-F-N5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
11340 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS AU6264700
HS Code 2933990090
37076-78-1 structure

37076-78-1

~%

700-49-2 structure

700-49-2

Literature: WO2006/81665 A1, ; Page/Page column 26-27 ;
143482-58-0 structure

143482-58-0

~%

700-49-2 structure

700-49-2

Literature: US5180824 A1, ;
109-80-8 structure

109-80-8

143482-58-0 structure

143482-58-0

~%

700-49-2 structure

700-49-2

Literature: US5180824 A1, ;
1904-98-9 structure

1904-98-9

~60%

700-49-2 structure

700-49-2

Literature: SAISCHEK, Gerald Patent: US2009/163713 A1, 2009 ; Location in patent: Page/Page column 2 ;
146-78-1 structure

146-78-1

~%

700-49-2 structure

700-49-2

72075-46-8 structure

72075-46-8

Literature: Nucleosides and Nucleotides, , vol. 18, # 4-5 p. 745 - 757
21679-12-9 structure

21679-12-9

~%

17039-17-7 structure

17039-17-7

700-49-2 structure

700-49-2

Literature: Nucleosides and Nucleotides, , vol. 18, # 4-5 p. 745 - 757
146-78-1 structure

146-78-1

~%

700-49-2 structure

700-49-2

18646-11-2 structure

18646-11-2

Literature: Nucleosides and Nucleotides, , vol. 18, # 4-5 p. 745 - 757
134217-15-5 structure

134217-15-5

~%

700-49-2 structure

700-49-2

850883-62-4 structure

850883-62-4

Literature: Nucleosides and Nucleotides, , vol. 18, # 4-5 p. 745 - 757
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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