Chromomycin A3
Modify Date: 2024-01-11 16:05:12
Chromomycin A3 structure
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Common Name | Chromomycin A3 | ||
|---|---|---|---|---|
| CAS Number | 7059-24-7 | Molecular Weight | 1183.25000 | |
| Density | 1.43g/cm3 | Boiling Point | 1147.6ºC at 760 mmHg | |
| Molecular Formula | C57H82O26 | Melting Point | 185℃ | |
| MSDS | Chinese USA | Flash Point | 311.1ºC | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
Use of Chromomycin A3Chromomycin A3 is an aureolic acid-type antitumor antibiotic. Chromomycin A3 forms dimeric complexes with divalent cations, such as Mg2+, which strongly binds to the GC rich sequence of DNA to inhibit DNA replication and transcription. Chromomycin A3 has a variety of utilities as a staining agent for human sperm chromatin, autophagy inducing agent, and apoptosis inhibitor[1]. |
| Name | chromomycin A3 |
|---|---|
| Synonym | More Synonyms |
| Description | Chromomycin A3 is an aureolic acid-type antitumor antibiotic. Chromomycin A3 forms dimeric complexes with divalent cations, such as Mg2+, which strongly binds to the GC rich sequence of DNA to inhibit DNA replication and transcription. Chromomycin A3 has a variety of utilities as a staining agent for human sperm chromatin, autophagy inducing agent, and apoptosis inhibitor[1]. |
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| Related Catalog | |
| References |
| Density | 1.43g/cm3 |
|---|---|
| Boiling Point | 1147.6ºC at 760 mmHg |
| Melting Point | 185℃ |
| Molecular Formula | C57H82O26 |
| Molecular Weight | 1183.25000 |
| Flash Point | 311.1ºC |
| Exact Mass | 1182.51000 |
| PSA | 359.34000 |
| LogP | 1.54640 |
| Index of Refraction | 1.608 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Symbol |
GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300-H360 |
| Precautionary Statements | P201-P264-P301 + P310-P308 + P313 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T+,T |
| Risk Phrases | 61-28 |
| Safety Phrases | S28;S45;S53;S36/S37/S39 |
| RIDADR | UN 3462 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | GB7875000 |
| Packaging Group | I |
| Hazard Class | 6.1(a) |
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High diversity in CMA3/DAPI-banding patterns in Heteropterans.
Cytogenet. Genome Res. 142(1) , 46-53, (2014) Heteroptera is the most numerous and diverse suborder of Hemiptera, with about 38,000 species. This diversity also involves cytogenetic features, including chromosome number and a sex determining syst... |
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Association of aureolic acid antibiotic, chromomycin A3 with Cu2+ and its negative effect upon DNA binding property of the antibiotic.
Biometals 25(2) , 435-50, (2012) Here we have examined the association of an aureolic acid antibiotic, chromomycin A3 (CHR), with Cu(2+). CHR forms a high affinity 2:1 (CHR:Cu(2+)) complex with dissociation constant of 0.08 × 10(-10)... |
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Evaluation of sperm's chromatin quality with acridine orange test, chromomycin A3 and aniline blue staining in couples with unexplained recurrent abortion.
J. Assist. Reprod. Genet. 26(11-12) , 591-6, (2009) To evaluate the sperm's chromatin quality in couples with spontaneous recurrent abortion.Thirty couples with spontaneous recurrent abortion (case group) and 30 fertile couples (control group) referrin... |
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