Veratric acid

Modify Date: 2024-01-02 11:49:31

Veratric acid structure	Common Name	Veratric acid
	CAS Number	93-07-2	Molecular Weight	182.173
	Density	1.2±0.1 g/cm3	Boiling Point	302.9±22.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₀O₄	Melting Point	179-182 °C(lit.)
	MSDS	Chinese USA	Flash Point	120.9±15.8 °C
	Symbol	GHS07	Signal Word	Warning

Use of Veratric acid

Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3].

Name	3,4-dimethoxybenzoic acid
Synonym	More Synonyms

Description	Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3].
Related Catalog	Natural Products >> Acids and Aldehydes Research Areas >> Inflammation/Immunology Research Areas >> Cardiovascular Disease
Target	COX-2[3]
In Vitro	Veratric acid (100, 200 μM) suppresses iNOS expression in LPS-stimulated RAW264.7 cells. Veratric acid (200 μM) inhibits LPS-induced activation of the PI3K/Akt pathway, HAT activation and HDAC3 expression in RAW264.7 cells[1]. Veratric Acid (10-100 μg/mL) has anti-inflammatory activity, protects HaCaT cells against UVB-mediated phototoxicity, increases S-phase cells, and prevents UVB-mediated apoptosis[3]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3].
In Vivo	Veratric acid (40 mg/kg, p.o., b.w.) significantly promotes ventricular function, reduces lipid peroxidation and increases antioxidants in l-NAME-induced hypertensive rats[2].
References	[1]. Choi WS, et al. Veratric acid inhibits iNOS expression through the regulation of PI3K activation and histone acetylation in LPS-stimulated RAW264.7 cells. Int J Mol Med. 2015 Jan;35(1):202-10. [2]. Saravanakumar M, et al. Oral administration of veratric acid, a constituent of vegetables and fruits, prevents cardiovascular remodelling in hypertensive rats: a functional evaluation. Br J Nutr. 2015 Nov 14;114(9):1385-94. [3]. Shin SW, et al. Antagonist effects of veratric acid against UVB-induced cell damages. Molecules. 2013 May 10;18(5):5405-19.

Density	1.2±0.1 g/cm3
Boiling Point	302.9±22.0 °C at 760 mmHg
Melting Point	179-182 °C(lit.)
Molecular Formula	C₉H₁₀O₄
Molecular Weight	182.173
Flash Point	120.9±15.8 °C
Exact Mass	182.057907
PSA	55.76000
LogP	1.99
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.533
Storage condition	Refrigerator
Stability	Stable. Incompatible with strong oxidizing agents.
Water Solubility	slightly soluble

Veratric acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG8598750

CHEMICAL NAME :: Benzoic acid, 3,4-dimethoxy-

CAS REGISTRY NUMBER :: 93-07-2

BEILSTEIN REFERENCE NO. :: 0518285

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H10-O4

MOLECULAR WEIGHT :: 182.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 1 mmol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 29,1275,1980

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DG8598750
HS Code	2918990090

Precursor 10
CAS#:93-03-8 3,4-Dimethoxybe... CAS#:120-14-9 veratraldehyde CAS#:90807-80-0 4-(azidomethyl)... CAS#:99-50-3 protocatechuic acid
CAS#:64-17-5 Ethanol CAS#:77-78-1 Dimethyl sulfate CAS#:1131-62-0 3,4-Dimethoxyac... CAS#:2150-38-1 Methyl 3,4-dime...
CAS#:114131-33-8 1,2-dimethoxy-4... CAS#:10535-17-8 1-(3,4-Dimethox...
DownStream 10
CAS#:111427-22-6 (3,4-dimethoxyp... CAS#:4302-52-7 4-Ethynyl-1,2-d... CAS#:3897-89-0 4-Hydroxymethyl... CAS#:498-00-0 Vanillyl alcohol
CAS#:93-03-8 3,4-Dimethoxybe... CAS#:5653-46-3 2-hydroxy-3,4-d... CAS#:3943-77-9 Ethyl 3,4-Dimet... CAS#:3943-74-6 Methyl vanillate
CAS#:37527-66-5 Benzene,4-isocy... CAS#:4143-62-8 3',4'-dimethoxy...

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Quantitative measurement of organic acids in tissues from gastric cancer patients indicates increased glucose metabolism in gastric cancer.

PLoS ONE 9(6) , e98581, (2014)

The levels of organic acids representing metabolic pathway end products are important indicators of physiological status, and may be associated with metabolic changes in cancer. The aim of this study ...

Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site.

Bioorg. Med. Chem. 19 , 1381-9, (2011)

Carbonic anhydrases (CAs, EC 4.2.1.1) are inhibited by sulfonamides, inorganic anions, phenols, coumarins (acting as prodrugs) and polyamines. A novel class of CA inhibitors (CAIs), interacting with t...

The regulatory effect of veratric acid on NO production in LPS-stimulated RAW264.7 macrophage cells.

Cell. Immunol. 280(2) , 164-70, (2012)

Veratric acid, a simple benzoic acid derived from plants and fruits, has been reported to have anti-oxidant, anti-inflammation, and blood pressure-lowering effects. This study was designed to evaluate...

MFCD00002500

EINECS 202-215-7

Benzoic acid, 3,4-dimethoxy-

3,4-Dimethoxybenzoic acid

Veratric acid

BioBioPha
China
Product Name: Veratric acid
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Veratric acid
Price: ￥78.0/25g ￥218.0/100g ￥708.0/500g ￥178.0/20mg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 3,4-Dimethoxybenzoic acid
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3,4-Dimethoxybenzoic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 3,4-dimethoxybenzoic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Veratric acid

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