Sulfobromophthalein disodium salt

Modify Date: 2026-07-14 12:20:41

Sulfobromophthalein disodium salt structure	Common Name	Sulfobromophthalein disodium salt
	CAS Number	71-67-0	Molecular Weight	837.99700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₈Br₄Na₂O₁₀S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Sulfobromophthalein disodium salt

Sulfobromophthalein (Bromosulfophthalein) disodium salt is an organic anion dye used in the study of a variety of membrane carriers expressed in animal tissues and involved in transport of drugs and metabolites[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	bromosulfophthalein sodium
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Sulfobromophthalein (Bromosulfophthalein) disodium salt is an organic anion dye used in the study of a variety of membrane carriers expressed in animal tissues and involved in transport of drugs and metabolites[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	Sulfobromophthalein disodium salt is a synthetic dye introduced in 1925 as a clinical tool aiming at the assessment of the liver function[1]. Sulfobromophthalein (BSP) is a pH indicator dye, featured by fast (17), protondependent quinoidal–phenolic tautomerism (pK = 8.5) [1]. Bromosulfalein has been commonly used as both a substrate and inhibitor of organic anionic transporting polypeptide 1B1 (OATP1B1), OATP1B3, OATP1A2, and OATP2B1, as well as multidrug resistance protein 2 (MDR2) [2].
References	[1]. Saki Izumi, et al. Substrate-dependent inhibition of organic anion transporting polypeptide 1B1: comparative analysis with prototypical probe substrates estradiol-17β-glucuronide, estrone-3-sulfate, and sulfobromophthalein. Drug Metab Dispos. 2013 Oct;41(10):1859-66.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Molecular Formula	C₂₀H₈Br₄Na₂O₁₀S₂
Molecular Weight	837.99700
Exact Mass	833.60900
PSA	205.76000
LogP	6.57600
InChIKey	GHAFORRTMVIXHS-UHFFFAOYSA-L
SMILES	O=C1OC(c2ccc([O-])c(S(=O)(=O)O)c2)(c2ccc([O-])c(S(=O)(=O)O)c2)c2c(Br)c(Br)c(Br)c(Br)c21.[Na+].[Na+]

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Sulfobromophthalein disodium salt MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SM8395000

CHEMICAL NAME :: Phenolphthalein, 4,5,6,7-tetrabromo-3',3''-disulfo-, disodium salt

CAS REGISTRY NUMBER :: 71-67-0

LAST UPDATED :: 199712

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C20-H8-Br4-O10-S2.2Na

MOLECULAR WEIGHT :: 838.02

WISWESSER LINE NOTATION :: T56 BVO DHJ DR DQ CSWO& DR DQ CSWO& FE GE HE IE &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 334 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,394,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 24,265,1925

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 24,265,1925 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6097 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 314 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes	Xn
Risk Phrases	R42/43
Safety Phrases	S24/25
WGK Germany	3
RTECS	SM8395000

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: TP_TRANSPORTER: inhibition of Gadoxetate uptake (Gadoxetate: 100 uM, BSP: 10 uM) in X...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1A1
External Id: CHEMBL2076402

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: TP_TRANSPORTER: inhibition of Ouabain uptake (Ouabain: 100 uM, BSP: 100 uM) in Xenopu...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1A1
External Id: CHEMBL2076387

Name: TP_TRANSPORTER: inhibition of Ochratoxin A uptake (OTA: 1 uM, BSP: 100uM) in Xenopus ...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1A1
External Id: CHEMBL2076393

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Total 333, Current Page 1 of 34

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

EINECS 200-761-0

MFCD00150017

Bromosulphthalein

Bromsulphalein

Bromsulfalein

Hepatosulfalein

Sodium bromsulphalein

Sodium bromosulfophthalein

disodium,2-hydroxy-5-[4,5,6,7-tetrabromo-1-(4-hydroxy-3-sulfonatophenyl)-3-oxo-2-benzofuran-1-yl]benzenesulfonate

Bromosulfophthalein

Sulfobromophthalein

Bromthalein

Sodium bromosulfalein

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the LogP of bromosulfophthalein sodium?

A: LogP of bromosulfophthalein sodium is 6.57600.

Q: What is the CAS number of bromosulfophthalein sodium?

A: CAS number of bromosulfophthalein sodium is 71-67-0.

Q: What is the molecular weight of bromosulfophthalein sodium?

A: Molecular weight of bromosulfophthalein sodium is 837.99700.

Q: What is the English name of bromosulfophthalein sodium?

A: The English name of bromosulfophthalein sodium is bromosulfophthalein sodium.

Q: What is the polar surface area (PSA) of bromosulfophthalein sodium?

A: Polar surface area (PSA) of bromosulfophthalein sodium is 205.76000.

Q: What are the uses of bromosulfophthalein sodium?

A: Main uses of bromosulfophthalein sodium: Sulfobromophthalein (Bromosulfophthalein) disodium salt is an organic anion dye used in the study of a variety of membrane carriers expressed in animal tissues and involved in transport of drugs and metabolites[1].

Q: What is the SMILES notation of bromosulfophthalein sodium?

A: SMILES notation of bromosulfophthalein sodium is O=C1OC(c2ccc([O-])c(S(=O)(=O)O)c2)(c2ccc([O-])c(S(=O)(=O)O)c2)c2c(Br)c(Br)c(Br)c(Br)c21.[Na+].[Na+].

Q: What English synonyms does bromosulfophthalein sodium have?

A: English synonyms of bromosulfophthalein sodium: EINECS 200-761-0, MFCD00150017, Bromosulphthalein, Bromsulphalein, Bromsulfalein, Hepatosulfalein, Sodium bromsulphalein, Sodium bromosulfophthalein, disodium,2-hydroxy-5-[4,5,6,7-tetrabromo-1-(4-hydroxy-3-sulfonatophenyl)-3-oxo-2-benzofuran-1-yl]benzenesulfonate, Bromosulfophthalein, Sulfobromophthalein, Bromthalein, Sodium bromosulfalein.

Q: What is the molecular formula of bromosulfophthalein sodium?

A: Molecular formula of bromosulfophthalein sodium is C20H8Br4Na2O10S2.

Q: What is the safety information for bromosulfophthalein sodium?

A: Safety information for bromosulfophthalein sodium: S24/25.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Sulfobromophthalein disodium salt
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: disodium 6,6'-dihydroxy-3,3'-(4,5,6,7-tetrabromo-1,3-dihydro-3-oxoisobenzofuran-1-ylidene)dibenzenesulphonate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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