Gonadorelin diacetate
Modify Date: 2024-01-03 16:50:29
Gonadorelin diacetate structure
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Common Name | Gonadorelin diacetate | ||
|---|---|---|---|---|
| CAS Number | 71447-49-9 | Molecular Weight | 1302.41 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C55H75N17O13.2C2H4O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS08 |
Signal Word | Danger | |
Use of Gonadorelin diacetateLuteinizing Hormone Releasing Hormone (LH-RH), human is hypothalamic neuropeptide which plays a key role in the control of reproductive functions. |
| Name | Luteinizing hormone releasing hormone human acetate salt |
|---|---|
| Synonym | More Synonyms |
| Description | Luteinizing Hormone Releasing Hormone (LH-RH), human is hypothalamic neuropeptide which plays a key role in the control of reproductive functions. |
|---|---|
| Related Catalog | |
| In Vitro | Luteinizing Hormone Releasing Hormone (LH-RH), also called gonadotropin-releasing hormone (GnRH), is the primary link between the brain, the pituitary and gonadal function, and has a key role in vertebrate reproduction. The endocrine actions of Luteinizing Hormone Releasing Hormone (LH-RH) and its analogs are mediated by high-affinity membrane receptors for LHRH on pituitary gonadotrophs[1]. LHRH is expressed,together with its receptors,in hormonerelated tumors such as prostate cancer,to act as a local autocrine/paracrine growth inhibitory factor. In prostate cancer cells,the LHRH receptor is coupled to the Gi-cAMP pathway to inhibit cell proliferation[3]. |
| In Vivo | Luteinizing Hormone Releasing Hormone treatment advances the timing of vaginal opening by 5 days, which is used as an initial indicator for the time of puberty[2]. |
| Animal Admin | Rats[2] Immature female Sprague-Dawley rats receive either 50 ng Luteinizing Hormone Releasing Hormone (LH-RH)/kg BW or 20 mg NMA/kg BW in a 10% dextrose, 0.9% NaCl solution, while controls receive only vehicle. After completion of the treatment, rats are examined daily for vaginal opening[2]. |
| References |
| Molecular Formula | C55H75N17O13.2C2H4O2 |
|---|---|
| Molecular Weight | 1302.41 |
| PSA | 546.73000 |
| LogP | 1.28920 |
| Storage condition | −20°C |
| Water Solubility | H2O: 25 mg/mL, clear, faintly yellow |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H360 |
| Precautionary Statements | P201-P308 + P313 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Phrases | R60 |
| Safety Phrases | 53-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | OK6470000 |
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Reduced melanocortin production causes sexual dysfunction in male mice with POMC neuronal insulin and leptin insensitivity.
Endocrinology 156(4) , 1372-85, (2015) Proopiomelanocortin (POMC)-derived peptides like α-melanocyte-stimulating hormone (MSH) substantially improve hepatic insulin sensitivity and regulate energy expenditure. Melanocortinergic agents are ... |
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Developmental programming: impact of prenatal testosterone excess on pre- and postnatal gonadotropin regulation in sheep.
Biogerontology 78 , 648-60, (2008) The goal of this study was to explore mechanisms that mediate hypersecretion of LH and progressive loss of cyclicity in female sheep exposed during fetal life to excess testosterone. Our working hypot... |
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GnRH receptor and apoptotic signaling.
Vitam. Horm. 59 , 1-33, (2000) In addition to its hypophysiotropic action, gonadotropin-releasing hormone (GnRH) can modify activity in extrapituitary organs and peripheral tumors. GnRH analogs are the preferred treatment for advan... |
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| Gonadorelin acetate |
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| Gonadorelin diacetate |
| Luteinizing Hormone Releasing Hormone LH-RH |
| Luteinizing Hormone Releasing Hormone (LH-RH), human |