Ampicillin Trihydrate
Ampicillin Trihydrate structure
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Common Name | Ampicillin Trihydrate | ||
|---|---|---|---|---|
| CAS Number | 7177-48-2 | Molecular Weight | 403.451 | |
| Density | N/A | Boiling Point | 683.9ºC at 760 mmHg | |
| Molecular Formula | C16H25N3O7S | Melting Point | 208 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 367.4ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
Use of Ampicillin TrihydrateAmpicillin trihydrate (D-(-)-α-Aminobenzylpenicillin trihydrate) is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | ampicillin trihydrate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Ampicillin trihydrate (D-(-)-α-Aminobenzylpenicillin trihydrate) is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria. |
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| Related Catalog | |
| In Vitro | Ampicillin trihydrate (D-(-)-α-Aminobenzylpenicillin trihydrate) inhibits the growth of E. coli of swine origin in a dose-dependent manner. The effective inhibitory concentration of Ampicillin trihydrate is 2.5 uG/mL[1]. |
| In Vivo | Ampicillin trihydrate (D-(-)-α-Aminobenzylpenicillin trihydrate) is very effective in alleviating the symptoms of hemorrhagic enteritis in a 11-week old pig[1]. Ampicillin trihydrate produces maximum concentrations in bile twice as high as in serum. The peak concentration of ampicillin after an oral dose is as twice as high in portal blood as in peripheral blood[2]. Ampicillin trihydrate provides neuroprotection against ischemia-reperfusion brain injury. Ampicillin trihydrate reduces the activities of MMPs and increases the expression level of GLT-1. Pretreatment with Ampicillin trihydrate significantly reduces medial hippocampal cell death following global forebrain ischemia[3]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 683.9ºC at 760 mmHg |
|---|---|
| Melting Point | 208 °C (dec.)(lit.) |
| Molecular Formula | C16H25N3O7S |
| Molecular Weight | 403.451 |
| Flash Point | 367.4ºC |
| Exact Mass | 403.141327 |
| PSA | 165.72000 |
| LogP | 1.15430 |
| Index of Refraction | 265 ° (C=0.1, H2O) |
| InChIKey | RXDALBZNGVATNY-CWLIKTDRSA-N |
| SMILES | CC1(C)SC2C(NC(=O)C(N)c3ccccc3)C(=O)N2C1C(=O)O.O.O.O |
| Water Solubility | 0.1-1 g/100 mL at 21 ºC |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H315-H317-H319-H334-H335 |
| Precautionary Statements | P261-P280-P284-P304 + P340-P305 + P351 + P338-P342 + P311 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R36/37/38;R42/43 |
| Safety Phrases | S22-S26-S36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | XH8425000 |
| HS Code | 2941101100 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2941101100 |
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This table lists relevant public references with title, journal and publication metadata for this compound.
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Fine mapping and characterization of the L-polymerase-binding domain of the respiratory syncytial virus phosphoprotein.
J. Virol. 89(8) , 4421-33, (2015) The minimum requirement for an active RNA-dependent RNA polymerase of respiratory syncytial virus (RSV) is a complex made of two viral proteins, the polymerase large protein (L) and the phosphoprotein... |
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BBS4 directly affects proliferation and differentiation of adipocytes.
Cell. Mol. Life Sci. 71(17) , 3381-92, (2014) BBS4 is one of several proteins whose defects cause Bardet-Biedl syndrome (BBS), a multi-systemic disorder, manifesting with marked obesity. BBS4 polymorphisms have been associated with common non-syn... |
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An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence.
Proc. Natl. Acad. Sci. U. S. A. 112(7) , E747-56, (2015) The nucleotide cyclic di-3',5'- adenosine monophosphate (c-di-AMP) was recently identified as an essential and widespread second messenger in bacterial signaling. Among c-di-AMP-producing bacteria, al... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Ampicillin |
| MFCD00072036 |
| EINECS 200-709-7 |
| Ampicillin Trihydrate |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the uses of ampicillin trihydrate? |
| A: Main uses of ampicillin trihydrate: Ampicillin trihydrate (D-(-)-α-Aminobenzylpenicillin trihydrate) is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria. |
| Q: What is the molecular weight of ampicillin trihydrate? |
| A: Molecular weight of ampicillin trihydrate is 403.451. |
| Q: What is the SMILES notation of ampicillin trihydrate? |
| A: SMILES notation of ampicillin trihydrate is CC1(C)SC2C(NC(=O)C(N)c3ccccc3)C(=O)N2C1C(=O)O.O.O.O. |
| Q: What is the InChIKey of ampicillin trihydrate? |
| A: InChIKey of ampicillin trihydrate is RXDALBZNGVATNY-CWLIKTDRSA-N. |
| Q: What English synonyms does ampicillin trihydrate have? |
| A: English synonyms of ampicillin trihydrate: Ampicillin, MFCD00072036, EINECS 200-709-7, Ampicillin Trihydrate. |
| Q: What is the polar surface area (PSA) of ampicillin trihydrate? |
| A: Polar surface area (PSA) of ampicillin trihydrate is 165.72000. |
| Q: What is the English name of ampicillin trihydrate? |
| A: The English name of ampicillin trihydrate is ampicillin trihydrate. |
| Q: What is the boiling point of ampicillin trihydrate? |
| A: Boiling point of ampicillin trihydrate is 683.9ºC at 760 mmHg. |
| Q: What is the CAS number of ampicillin trihydrate? |
| A: CAS number of ampicillin trihydrate is 7177-48-2. |
| Q: What is the safety information for ampicillin trihydrate? |
| A: Safety information for ampicillin trihydrate: S22-S26-S36/37. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |