Vidofludimus

Modify Date: 2024-01-08 06:20:04

Vidofludimus Structure
Vidofludimus structure
 Common Name Vidofludimus
CAS Number 717824-30-1 Molecular Weight 355.360
Density 1.4±0.1 g/cm3 Boiling Point 567.5±50.0 °C at 760 mmHg
Molecular Formula C20H18FNO4 Melting Point N/A
MSDS N/A Flash Point 297.0±30.1 °C

 Use of Vidofludimus


Vidofludimus(4SC-101; SC12267) is a novel immunosuppressive drug that inhibits DHODH; inhibits IL-17 secretion in vitro independently of effects on lymphocyte proliferation.IC50 value:Target: DHODH inhibitorin vitro: 4SC-101 is a potent inhibitor of human DHODH, inhibits lymphocyte proliferation, and uniquely blocks phytohemagglutinin-stimulated IL-17 production by lymphocytes [2].in vivo: In vivo Vido treatment alone most effectively reduced macroscopic and histological pathology and the numbers of CD3+ T cells. In contrast, similarly reduced nuclear signal transducer and activator of transcription 3 (STAT3) binding and IL-17 levels were observed from animals treated with Vido alone and Vido + Uri. Vido improves TNBS-induced colonic inflammation by a unique dual mode of action [1]. Oral administration of 4SC-101 effectively improved both chronic DSS and acute TNBS colitis in mice. In these colitis models the overall efficacy profile of 4SC-101 was similar to that of dexamethasone [2].

 Names

Name 2-[[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylic acid
Synonym More Synonyms

 Vidofludimus Biological Activity

Description Vidofludimus(4SC-101; SC12267) is a novel immunosuppressive drug that inhibits DHODH; inhibits IL-17 secretion in vitro independently of effects on lymphocyte proliferation.IC50 value:Target: DHODH inhibitorin vitro: 4SC-101 is a potent inhibitor of human DHODH, inhibits lymphocyte proliferation, and uniquely blocks phytohemagglutinin-stimulated IL-17 production by lymphocytes [2].in vivo: In vivo Vido treatment alone most effectively reduced macroscopic and histological pathology and the numbers of CD3+ T cells. In contrast, similarly reduced nuclear signal transducer and activator of transcription 3 (STAT3) binding and IL-17 levels were observed from animals treated with Vido alone and Vido + Uri. Vido improves TNBS-induced colonic inflammation by a unique dual mode of action [1]. Oral administration of 4SC-101 effectively improved both chronic DSS and acute TNBS colitis in mice. In these colitis models the overall efficacy profile of 4SC-101 was similar to that of dexamethasone [2].
Related Catalog
References

[1]. Fitzpatrick LR, et al. Vidofludimus inhibits colonic interleukin-17 and improves hapten-induced colitis in rats by a unique dual mode of action. J Pharmacol Exp Ther. 2012 Sep;342(3):850-60.

[2]. Fitzpatrick LR, et al. 4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2010 Oct;16(10):1763-77.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 567.5±50.0 °C at 760 mmHg
Molecular Formula C20H18FNO4
Molecular Weight 355.360
Flash Point 297.0±30.1 °C
Exact Mass 355.121979
PSA 79.12000
LogP 4.22
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.634
Storage condition -20℃

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

2-[(3-Fluoro-3'-methoxy-4-biphenylyl)carbamoyl]-1-cyclopentene-1-carboxylic acid
4SC-101
2-(3-Fluoro-3'-methoxy-biphenyl-4-ylcarbamoyl)-cyclopent-1-ene-carboxylic acid
1-Cyclopentene-1-carboxylic acid, 2-[[(3-fluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]carbonyl]-
2-((3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid
Vidofludimus [INN]
2-[(3-Fluoro-3'-methoxybiphenyl-4-yl)carbamoyl]cyclopent-1-ene-1-carboxylic acid
Vidofludimus
SC12267
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Related Compounds: More...
vidofludimus
1289942-66-0
Vidofludimus methyl ester
719301-50-5
Chemsrc provides Vidofludimus(CAS#:717824-30-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Vidofludimus are included as well.>> amp version: Vidofludimus

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