Vidofludimus

• 常用名: Vidofludimus
• 英文名: Vidofludimus
• CAS号: 717824-30-1
• 分子量: 355.360
• 密度: 1.4±0.1 g/cm3
• 沸点: 567.5±50.0 °C at 760 mmHg
• 分子式: C₂₀H₁₈FNO₄
• 熔点: N/A
• 闪点: 297.0±30.1 °C

Vidofludimus用途

Vidofludimus(4SC-101; SC12267)是免疫抑制剂,能抑制DHODH,在不影响淋巴细胞增殖的条件下抑制IL-17的分泌。

Vidofludimus名称

• 中文名: Vidofludimus
• 英文名: 2-[[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylic acid

Vidofludimus生物活性

• 描述: Vidofludimus(4SC-101; SC12267)是免疫抑制剂,能抑制DHODH,在不影响淋巴细胞增殖的条件下抑制IL-17的分泌。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 白细胞介素相关
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Fitzpatrick LR, et al. Vidofludimus inhibits colonic interleukin-17 and improves hapten-induced colitis in rats by a unique dual mode of action. J Pharmacol Exp Ther. 2012 Sep;342(3):850-60.

  [2]. Fitzpatrick LR, et al. 4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2010 Oct;16(10):1763-77.

Vidofludimus物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 567.5±50.0 °C at 760 mmHg
• 分子式: C₂₀H₁₈FNO₄
• 分子量: 355.360
• 闪点: 297.0±30.1 °C
• 精确质量: 355.121979
• PSA: 79.12000
• LogP: 4.22
• InChIKey: XPRDUGXOWVXZLL-UHFFFAOYSA-N
• SMILES: COc1cccc(-c2ccc(NC(=O)C3=C(C(=O)O)CCC3)c(F)c2)c1
• 外观性状: 粉末
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.634
• 储存条件: -20℃

Vidofludimus英文别名

• 2-[(3-Fluoro-3'-methoxy-4-biphenylyl)carbamoyl]-1-cyclopentene-1-carboxylic acid
• 4SC-101
• 2-(3-Fluoro-3'-methoxy-biphenyl-4-ylcarbamoyl)-cyclopent-1-ene-carboxylic acid
• 1-Cyclopentene-1-carboxylic acid, 2-[[(3-fluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]carbonyl]-
• 2-((3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid
• Vidofludimus [INN]
• 2-[(3-Fluoro-3'-methoxybiphenyl-4-yl)carbamoyl]cyclopent-1-ene-1-carboxylic acid
• Vidofludimus
• SC12267