p,p'-DDE

Modify Date: 2024-01-06 14:54:27

p,p'-DDE structure	Common Name	p,p'-DDE
	CAS Number	72-55-9	Molecular Weight	318.025
	Density	1.4±0.1 g/cm3	Boiling Point	383.1±37.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₈Cl₄	Melting Point	88-90 °C(lit.)
	MSDS	Chinese USA	Flash Point	183.7±23.9 °C
	Symbol	GHS02, GHS06, GHS08, GHS09	Signal Word	Danger

Use of p,p'-DDE

p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[1].

Name	dde
Synonym	More Synonyms

Description	p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Androgen Receptor
References	[1]. Kelce WR, et al. Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist. Nature. 1995;375(6532):581-585.

Density	1.4±0.1 g/cm3
Boiling Point	383.1±37.0 °C at 760 mmHg
Melting Point	88-90 °C(lit.)
Molecular Formula	C₁₄H₈Cl₄
Molecular Weight	318.025
Flash Point	183.7±23.9 °C
Exact Mass	315.938019
LogP	6.37
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.622
Stability	Stable, but light-sensitive. Incompatible with strong bases, strong oxidizing agents.

p,p'-DDE MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KV9450000

CHEMICAL NAME :: Ethylene, 1,1-dichloro-2,2-bis(p-chlorophenyl)-

CAS REGISTRY NUMBER :: 72-55-9

BEILSTEIN REFERENCE NO. :: 1913355

LAST UPDATED :: 199710

DATA ITEMS CITED :: 42

MOLECULAR FORMULA :: C14-H8-Cl4

MOLECULAR WEIGHT :: 318.02

WISWESSER LINE NOTATION :: GYGUYR DG&R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 880 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 504 mg/kg/6W-C

TOXIC EFFECTS :: Liver - changes in liver weight Immunological Including Allergic - decrease in cellular immune response Immunological Including Allergic - decrease in humoral immune response

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 586 mg/kg/28D-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - domestic

DOSE/DURATION :: 76160 ug/kg/8W-C

TOXIC EFFECTS :: Autonomic Nervous System - sympathomimetic Liver - changes in liver weight Biochemical - Neurotransmitters or modulators (putative) - dopamine at other sites

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9700 mg/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 36 gm/kg/86W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Endocrine - adrenal cortex tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 gm/kg/80W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 57 gm/kg/68W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Endocrine - adrenal cortex tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 41 gm/kg/97W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Endocrine - adrenal cortex tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 81 gm/kg/97W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Endocrine - adrenal cortex tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 3500 ug/kg

SEX/DURATION :: female 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,137,1984 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 5,83,1974 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,179,1991 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,179,1991 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,179,1991 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 48,141,1973

Symbol	GHS02, GHS06, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370-H411
Precautionary Statements	P210-P260-P273-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R33
Safety Phrases	36/37-60-61-45-16-7-62
RIDADR	UN 3077 9/PG 3
WGK Germany	3
RTECS	KV9450000
HS Code	2903999090

HS Code	2903999090
Summary	2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Risk assessment for children exposed to DDT residues in various milk types from the Greek market.

Food Chem. Toxicol. 75 , 156-65, (2015)

The occurrence of residues of DDT and its metabolites was monitored in 196 cow milk samples of various pasteurized commercial types collected from the Greek market. Residue levels were determined by G...

Three decades (1983-2010) of contaminant trends in East Greenland polar bears (Ursus maritimus). Part 1: legacy organochlorine contaminants.

Environ. Int. 59 , 485-93, (2013)

Legacy organochlorine contaminants were determined in adipose tissues from 294 polar bears (Ursus maritimus) sampled in East Greenland in 23 of the 28years between 1983 and 2010. Of 19 major legacy co...

Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

J. Med. Chem. 48 , 5666-74, (2005)

We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular d...

Benzene, 1,1'-(dichloroethenylidene)bis[4-chloro-

DDE

p,p'-DDE

1,1-bis(4-chlorophenyl)-2,2-dichloroethylene

2,2-Bis(4-chlorophenyl)-1,1-dichloroethylene

dichlorodiphenyldichloroethylene

para,para'-DDE

EINECS 200-784-6

DDE, p,p'-

1,1'-(2,2-dichloroethene-1,1-diyl)bis(4-chlorobenzene)

Benzene, 1,1'-(2,2-dichloroethenylidene)bis[4-chloro-

MFCD00003284

p,p'-Dichlorodiphenyldichloroethylene

1,1'-(2,2-Dichloro-1,1-ethenediyl)bis(4-chlorobenzene)

1,1-Bis(p-chlorophenyl)-2,2-dichloroethylene

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: p,p'-DDE
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Purity: 99.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: p,p'-DDE
Price: ￥Inquiry/1mg
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: DDE
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzene,1,1'-(2,2-dichloroethenylidene)bis[4-chloro-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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p,p'-DDE

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ACUTE TOXICITY DATA

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