Nortriptyline

Modify Date: 2026-07-04 19:30:31

Nortriptyline structure	Common Name	Nortriptyline
	CAS Number	72-69-5	Molecular Weight	263.37700
	Density	1.084 g/cm3	Boiling Point	403.4ºC at 760 mmHg
	Molecular Formula	C₁₉H₂₁N	Melting Point	N/A
	MSDS	N/A	Flash Point	194.9ºC

Use of Nortriptyline

Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant used to relieve the symptoms of depression. Nortriptyline is a potent autophagy inhibitor[1][2].

Summary: Nortriptyline, also known as去甲替林, has a CAS number of 72-69-5. Its molecular formula is C19H21N and molecular weight is 263.37700. It appears as a white solid with a boiling point of 403.4°C. For research-use only, not for medical or clinical usage.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	nortriptyline
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant used to relieve the symptoms of depression. Nortriptyline is a potent autophagy inhibitor[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Neurological Disease
References	[1]. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. In: Pratt VM, Scott SA, Pirmohamed M, et al., eds. Medical Genetics Summaries. Bethesda (MD): National Center for Biotechnology Information (US); March 23, 2017. [2]. Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022;10.1002/ijc.33965.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Neurological Disease

References

[1]. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. In: Pratt VM, Scott SA, Pirmohamed M, et al., eds. Medical Genetics Summaries. Bethesda (MD): National Center for Biotechnology Information (US); March 23, 2017.

[2]. Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022;10.1002/ijc.33965.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.084 g/cm3
Boiling Point	403.4ºC at 760 mmHg
Molecular Formula	C₁₉H₂₁N
Molecular Weight	263.37700
Flash Point	194.9ºC
Exact Mass	263.16700
PSA	12.03000
LogP	4.21730
Index of Refraction	1.633
InChIKey	PHVGLTMQBUFIQQ-UHFFFAOYSA-N
SMILES	CNCCC=C1c2ccccc2CCc2ccccc21
Storage condition	2-8°C

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HO9800000

CHEMICAL NAME :: 5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, 10,11-dihydro-N-methyl-

CAS REGISTRY NUMBER :: 72-69-5

LAST UPDATED :: 199707

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C19-H21-N

MOLECULAR WEIGHT :: 263.41

WISWESSER LINE NOTATION :: L C676 BY&T&J BU3M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 502 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia Behavioral - muscle contraction or spasticity

REFERENCE :: HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978- Volume(issue)/page/year: 55,527,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia Behavioral - muscle contraction or spasticity

REFERENCE :: HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978- Volume(issue)/page/year: 55,527,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1561,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,338,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,65,1974 *** REVIEWS *** TOXICOLOGY REVIEW DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 8,690,1974 TOXICOLOGY REVIEW CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955- Volume(issue)/page/year: 19,361,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4842 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2440 (estimated) No. of Female Employees: 1459 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

HS Code	2921499090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:4444-42-2 Desmethylnortri... CAS#:74-88-4 methyl iodide CAS#:50-48-6 Amitriptyline CAS#:16234-88-1 Ethyl [3-(10,11...
CAS#:16234-89-2 5-[3-(N-Carbeth... CAS#:2939-66-4 10,11-dihydro-5... CAS#:115107-86-3 3-(5-hydroxy-10... CAS#:1159-03-1 5-(3-dimethylam...
CAS#:40443-02-5 3-(10,11-dihydr...
DownStream 4
CAS#:50-48-6 Amitriptyline CAS#:4444-42-2 Desmethylnortri... CAS#:47132-19-4 (Z)-10-Hydroxy ... CAS#:47132-16-1 (E)-10-Hydroxyn...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2921499090
Summary	2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: pKa (acid-base dissociation constant) as determined by Avdeef ref: DOI: 10.1002/04714...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2449007

Name: Half life period is estimated
Source: ChEMBL
Target: N/A
External Id: CHEMBL633422

Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625

Name: pKa (acid-base dissociation constant) as determined by Luan ref: Pharm. Res. 2005
Source: ChEMBL
Target: N/A
External Id: CHEMBL2449009

Name: Apparent partition coefficient was measured as histamine releasing activity in rat ma...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL797214

Name: Lipophilicity, log D at pH7.4
Source: ChEMBL
Target: N/A
External Id: CHEMBL895152

Name: Drug activation in human Hep3B cells assessed as human CYP3A4-mediated drug metabolis...
Source: ChEMBL
Target: Cytochrome P450 3A4
External Id: CHEMBL4479035

Name: Acid dissociation constant, pKa of the compound
Source: ChEMBL
Target: N/A
External Id: CHEMBL895153

Name: Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 ...
Source: ChEMBL
Target: 5-hydroxytryptamine receptor 6
External Id: CHEMBL2157129

Total 540, Current Page 1 of 54

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Sesaval

Lumbeck

NORTRIPTYLINE

Ateben

noramitriptyline

Noritren

allegron

[14C]-Nortriptyline

desmethylamitriptyline

lambeck

EINECS 200-788-8

Aventyl

Psychostyl

notriptyline

Avantyl

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular formula of nortriptyline?

A: Molecular formula of nortriptyline is C19H21N.

Q: What is the LogP of nortriptyline?

A: LogP of nortriptyline is 4.21730.

Q: What are the downstream products of nortriptyline?

A: Related downstream products(CAS) of nortriptyline: 50-48-6;4444-42-2;47132-19-4;47132-16-1.

Q: What is the CAS number of nortriptyline?

A: CAS number of nortriptyline is 72-69-5.

Q: What English synonyms does nortriptyline have?

A: English synonyms of nortriptyline: Sesaval, Lumbeck, NORTRIPTYLINE, Ateben, noramitriptyline, Noritren, allegron, [14C]-Nortriptyline, desmethylamitriptyline, lambeck, EINECS 200-788-8, Aventyl, Psychostyl, notriptyline, Avantyl.

Q: What is the boiling point of nortriptyline?

A: Boiling point of nortriptyline is 403.4ºC at 760 mmHg.

Q: What is the SMILES notation of nortriptyline?

A: SMILES notation of nortriptyline is CNCCC=C1c2ccccc2CCc2ccccc21.

Q: What is the English name of nortriptyline?

A: The English name of nortriptyline is nortriptyline.

Q: What is the polar surface area (PSA) of nortriptyline?

A: Polar surface area (PSA) of nortriptyline is 12.03000.

Q: What is the molecular weight of nortriptyline?

A: Molecular weight of nortriptyline is 263.37700.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Nortriptyline
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: nortriptyline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Nortriptyline

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.