(E)-10-Hydroxynortriptyline

Modify Date: 2024-01-18 22:37:48

(E)-10-Hydroxynortriptyline Structure
(E)-10-Hydroxynortriptyline structure
Common Name (E)-10-Hydroxynortriptyline
CAS Number 47132-16-1 Molecular Weight 279.37600
Density 1.164g/cm3 Boiling Point 462.3ºC at 760mmHg
Molecular Formula C19H21NO Melting Point N/A
MSDS N/A Flash Point 142.1ºC

 Use of (E)-10-Hydroxynortriptyline


(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline (HY-B1417). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].

 Names

Name ()-trans-10-hydroxynortriptyline
Synonym More Synonyms

 (E)-10-Hydroxynortriptyline Biological Activity

Description (E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline (HY-B1417). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].
Related Catalog
References

[1]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8.

[2]. Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23.

 Chemical & Physical Properties

Density 1.164g/cm3
Boiling Point 462.3ºC at 760mmHg
Molecular Formula C19H21NO
Molecular Weight 279.37600
Flash Point 142.1ºC
Exact Mass 279.16200
PSA 32.26000
LogP 3.70820

 Synthetic Route

~91%

(E)-10-Hydroxynortriptyline Structure

(E)-10-Hydroxyn...

CAS#:47132-16-1

Literature: Jean-Claude; Just Synthetic Communications, 1994 , vol. 24, # 11 p. 1565 - 1573

~%

(E)-10-Hydroxynortriptyline Structure

(E)-10-Hydroxyn...

CAS#:47132-16-1

Literature: Jean-Claude; Just Synthetic Communications, 1994 , vol. 24, # 11 p. 1565 - 1573

~%

(E)-10-Hydroxynortriptyline Structure

(E)-10-Hydroxyn...

CAS#:47132-16-1

Literature: Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

~%

(E)-10-Hydroxynortriptyline Structure

(E)-10-Hydroxyn...

CAS#:47132-16-1

Literature: Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

~%

(E)-10-Hydroxynortriptyline Structure

(E)-10-Hydroxyn...

CAS#:47132-16-1

Literature: Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

~%

(E)-10-Hydroxynortriptyline Structure

(E)-10-Hydroxyn...

CAS#:47132-16-1

Literature: Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

~%

(E)-10-Hydroxynortriptyline Structure

(E)-10-Hydroxyn...

CAS#:47132-16-1

Literature: Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

~%

(E)-10-Hydroxynortriptyline Structure

(E)-10-Hydroxyn...

CAS#:47132-16-1

Literature: Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

~%

(E)-10-Hydroxynortriptyline Structure

(E)-10-Hydroxyn...

CAS#:47132-16-1

Literature: Masubuchi, Yasuhiro; Iwasa, Takashi; Fujita, Shoichi; Suzuki, Tokuji; Horie, Toshiharu; Narimatsu, Shizuo Journal of Pharmacy and Pharmacology, 1996 , vol. 48, # 9 p. 925 - 929

 Synonyms

E-10-hydroxynortriptyline
trans-10-Hydroxy Nortriptyline Maleate