Syk inhibitor II
Modify Date: 2024-01-04 10:49:26
Syk inhibitor II structure
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Common Name | Syk inhibitor II | ||
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| CAS Number | 726695-51-8 | Molecular Weight | 340.304 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 541.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C14H15F3N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 281.4±32.9 °C | |
Use of Syk inhibitor IISyk Inhibitor II is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II shows less potent against other kinases and has anti-allergic effect[1]. |
| Name | Syk Inhibitor II |
|---|---|
| Synonym | More Synonyms |
| Description | Syk Inhibitor II is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II shows less potent against other kinases and has anti-allergic effect[1]. |
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| Related Catalog | |
| Target |
serotonin:460 nM (IC50) Syk:41 nM (IC50) PKCε:5.1 μM (IC50) PKCβ2:11 μM (IC50) ZAP-70:11.2 μM (IC50) Btk:15.5 μM (IC50) Itk:22.6 μM (IC50) |
| In Vitro | Syk Inhibitor II (compound 9a) shows less potent against PKCε, PKCβ2, ZAP-70, Btk, and Itk with IC50 values of 5.1 µM, 11 µM, 11.2 µM, 15.5 µM, and 22.6 µM, respectively[1]. |
| In Vivo | Syk Inhibitor II (Compound 9a; 10-100 mg/kg) is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 541.6±60.0 °C at 760 mmHg |
| Molecular Formula | C14H15F3N6O |
| Molecular Weight | 340.304 |
| Flash Point | 281.4±32.9 °C |
| Exact Mass | 340.125946 |
| LogP | 1.25 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.633 |
| Storage condition | -20℃ |
| 5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]- |
| 2-[(2-Aminoethyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}-5-pyrimidinecarboxamide |
| Syk Inhibitor II |